Fragmentation of the Golgi apparatus of the ballooned neurons in patients with corticobasal degeneration and Creutzfeldt-Jakob disease
Fragmentation of the Golgi apparatus of the ballooned neurons in patients with corticobasal degeneration and Creutzfeldt-Jakob disease
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DOI：
10.1007/s004010000182
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发表时间：
2000-09-01
影响因子：
12.7
通讯作者：
Gonatas, NK
中科院分区：
文献类型：
--
作者：
Sakurai, A;Okamoto, K;Gonatas, NK
我们通过免疫组织学方法研究了两名皮质基底节变性患者和五名克雅氏病患者的皮质气球状神经元 (BN) 的高尔基体 (GA) 和跨高尔基体网络 (TGN)。我们观察到 BN 显示 GA 和 TGN 的碎片，伴随着碎片高尔基元件数量的减少和独特的核周分布。这是皮质 BN 中 GA 异常的首次报道。这些发现表明 GA 和 TGN 可能在 BN 形成中发挥一定作用。
We investigated immunohistologically the Golgi apparatus (GA) and the trans-Golgi network (TGN) of the cortical ballooned neurons (BNs) in two patients with corticobasal degeneration and in five with Creutzfeldt-Jakob disease. We observed that the BNs showed fragmentation of the GA and the TGN, accompanied by a reduction in the number of fragmented Golgi elements and by a unique perinuclear distribution. This is the first report of the abnormalities of GA in cortical BNs. These findings suggests that the GA and the TGN may play some roles in the BN formation.