Voltammetric determination of salicylic acid in pharmaceuticals formulations of acetylsalicylic acid
Voltammetric determination of salicylic acid in pharmaceuticals formulations of acetylsalicylic acid
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DOI：
10.1016/j.talanta.2003.07.005
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发表时间：
2004-02-06
期刊：
影响因子：
6.1
通讯作者：
Raba, J
中科院分区：
文献类型：
--
作者：
Torriero, AAJ;Luco, JM;Raba, J
采用循环伏安法和微分脉冲伏安法（DPV）在玻碳电极上研究了水杨酸（SA）的电化学氧化。 SA 在所研究的较宽 pH 范围内产生单一不可逆氧化波。通过不同的标准验证了电极过程的不可逆性。讨论了氧化机理。使用差分脉冲伏安法，SA 在 pH 2.37、1.088 V 的 Britton-Robinson 缓冲溶液中产生了明确的伏安响应（相对于 Ag/AgCl）。该方法在 SA 浓度范围内呈线性：1-60 mug ml(-1)。该方法成功应用于含有乙酰水杨酸 (ASA) 的固体药物制剂中水解产物 SA 的分析。 (C) 2003 Elsevier B.V. 保留所有权利。
The electrochemical oxidation of salicylic acid (SA) has been studied on a glassy carbon electrode using cyclic voltammetry and differential pulse voltammetric (DPV) method. SA gives a single irreversible oxidation wave over the wide pH range studied. The irreversibility of the electrode process was verified by different criteria. The mechanism of oxidation is discussed. Using differential pulse voltammetry, SA yielded a well-defined voltammetric response in Britton-Robinson buffer solution, pH 2.37 at 1.088 V (versus Ag/AgCl). The method was linear over the SA concentration range: 1-60 mug ml(-1). The method was successfully applied for the analysis of SA as a hydrolysis product, in solid pharmaceutical formulations containing acetylsalicylic acid (ASA). (C) 2003 Elsevier B.V. All rights reserved.