INFLUENZA-A VIRUS POTENTIATES BACTERIA-INDUCED HISTAMINE-RELEASE - EXAMINATION OF NORMAL INDIVIDUALS AND PATIENTS ALLERGIC TO BACTERIA
INFLUENZA-A VIRUS POTENTIATES BACTERIA-INDUCED HISTAMINE-RELEASE - EXAMINATION OF NORMAL INDIVIDUALS AND PATIENTS ALLERGIC TO BACTERIA
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DOI：
10.1111/j.1398-9995.1990.tb01098.x
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发表时间：
1990-08-01
期刊：
影响因子：
12.4
通讯作者：
NORN, S
中科院分区：
文献类型：
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作者：
CLEMENTSEN, P;PEDERSEN, M;NORN, S
发现甲型流感病毒可促进大肠杆菌、肠炎沙门氏菌、金黄色葡萄球菌、肺炎链球菌和血链球菌诱导的嗜碱性粒细胞组胺释放，但本身不释放组胺。当细菌诱导的介质释放依赖于IgE（即患者对细菌过敏）时，以及当细菌通过独立于IgE的非免疫机制（假定是糖凝集素介导）引起组胺释放时，都可以观察到病毒的增强作用。此外，其他免疫和非免疫刺激（如抗ige、钙离子载体或琼脂糖珠）诱导的组胺释放在病毒存在时也增强。病毒对细菌诱导的介质释放的增强作用可能是上呼吸道感染由潜伏性哮喘向显性哮喘转化的重要因素。
Influenza A virus was found to enhance basophil histamine release induced by Escherichia coli, Salmonella enteritidis, Staphylococcus aureus, Streptococcus pneumoniae and Streptococcus sanguis, but did not per se release histamine. This potentiating effect of the virus was seen both when the bacteria-induced mediator release was IgE-dependent (i.e. patient allergic to bacterium) and when the bacterium caused histamine release by a non-immunological mechanism independent of IgE (putative sugar-lectin mediated). Also histamine release induced by other immunological and non-immunological stimuli, such as anti-IgE, calcium ionophore or agarose beads was enhanced in the presence of the virus. The potentiating effect of the virus on bacteria-induced mediator release might be of importance for the conversion from latent to manifest asthma in upper respiratory tract infections.