A pooled analysis of the association between sarcopenia and osteoporosis.
A pooled analysis of the association between sarcopenia and osteoporosis.
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DOI：
10.1097/md.0000000000031692
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发表时间：
2022-11-18
期刊：
影响因子：
1.6
通讯作者：
Teng, Zhaowei
中科院分区：
文献类型：
--
作者：
Yu, Xiaochao;Sun, Shuo;Zhang, Shaoxiong;Hao, Qinggang;Zhu, Boheng;Teng, Yirong;Long, Qing;Li, Shujun;Lv, Yan;Yue, Qiaoning;Lu, Sheng;Teng, Zhaowei
肌肉减少症是一种进行性全身性骨骼肌疾病，导致肌肉质量和功能的加速丧失。骨质疏松症是一种全身性骨骼疾病，导致骨量和质量降低。一些研究表明，骨质疏松症和肌肉减少症是相互关联的;然而，一些研究表明，肌肉减少症和骨质疏松症之间缺乏显着关联。我们的目的是通过系统性综述和汇总分析来评估肌肉减少症和骨质疏松症之间的关联。从PubMed和Embase数据库成立到2022年9月，我们对评估肌肉减少症和骨质疏松症之间关系的研究进行了系统检索。研究评价和综合方法：我们纳入了提供95%置信区间（CI）和风险估计的观察性研究。两位评审员独立提取数据并评估研究质量。采用随机效应模型进行汇总分析，最终计算比值比（OR）和95% CI。主要统计量是肌肉减少症和骨质疏松症之间的相互风险。根据纳入标准，最终纳入了56项研究（796，914例受试者）。肌肉减少症与骨质疏松症的风险显著相关（OR，3.06; 95%CI，2.30 - 4.08），相对骨骼肌质量的每一个标准差增加与骨质疏松症风险的降低显著相关（OR，0.65; 95%CI，0.56 - 0.75）。骨质疏松症明显涉及肌肉减少症的风险较高（OR，2.63; 95%CI，1.98 - 3.49）。我们的研究表明，肌肉减少症和骨质疏松症是高度正相关。骨质疏松症与肌肉减少症的风险密切相关。我们的发现强调了肌肉减少症筛查对骨质疏松症风险的重要性，反之亦然。然而，在研究中注意到异质性，这可能影响了结果的准确性。因此，我们的研究结果应谨慎解释。
Sarcopenia is a progressive generalized skeletal muscle disorder that causes the accelerated loss of muscle mass and function. Osteoporosis is a systemic condition of the skeleton that results in low bone mass and quality. Several studies have suggested that osteoporosis and sarcopenia are interrelated; however, a few studies indicate the lack of a significant association between sarcopenia and osteoporosis. We aimed to evaluate the association between sarcopenia and osteoporosis via a systematic review and pooled analysis. From the inception of the PubMed and Embase databases until September 2022, we conducted a systematic search for studies evaluating the relationship between sarcopenia and osteoporosis. Study appraisal and synthesis methods: We included observational studies that provided 95% confidence intervals (CIs) and risk estimates. Two reviewers independently extracted data and assessed the quality of the research. The random-effects model was applied to the pool analysis, and the odds ratios (ORs) and 95% CIs were finally calculated. The primary statistic was the mutual risk between sarcopenia and osteoporosis. According to the inclusion criteria, 56 studies (796,914 participants) were finally included. Sarcopenia was significantly correlative to the risk of osteoporosis (OR, 3.06; 95% CI, 2.30–4.08), and each standard deviation increase in relative appendicular skeletal muscle mass was significantly related to a decreased risk of osteoporosis (OR, 0.65; 95% CI, 0.56–0.75). Osteoporosis observably referred to a higher risk of sarcopenia (OR, 2.63; 95% CI, 1.98–3.49). Our research indicated that sarcopenia and osteoporosis are highly positively correlated. Osteoporosis is closely associated with the risk of sarcopenia. Our finding highlights the importance of sarcopenia screening for those at risk of osteoporosis, and vice versa. However, heterogeneity was noted among the studies, and this might have influenced the accuracy of the results. Therefore, the results of our study should be interpreted with caution.