Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure
Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure
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DOI：
10.1016/j.ijcard.2010.12.016
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发表时间：
2012-05-17
影响因子：
3.5
通讯作者：
Rauchhaus, Mathias
中科院分区：
文献类型：
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作者：
Sandek, Anja;Bjarnason, Ingvar;Rauchhaus, Mathias
背景：失代偿期慢性心力衰竭(CHF)患者的小肠功能可能发生改变，而内毒素移位可能参与CHF的全身炎症反应。方法：用糖吸收技术检测20例CHF患者(12例水肿型和8例非水肿型)和8例对照组的肠道通透性(蜜二糖和鼠李糖)、主动性(3-O-甲基-D-葡萄糖(3-O-OMG)和被动性(D-木糖)载体介导的吸收)。我们还检测了42例失代偿期心力衰竭患者和代偿后患者的内毒素水平。结果：与对照组相比，CHF患者主动载体介导的肠道转运减少了54%(p
Background: Small intestinal function may be altered in decompensated chronic heart failure (CHF) and translocating LPS may contribute to systemic inflammation observed in CHF.Methods: We measured intestinal permeability (melibiose and rhamnose), active (3-O-methyl-D-glucose (3-OMG)) and passive (D-xylose) carrier-mediated absorption in 20 CHF patients (12 edematous and 8 non-edematous) and 8 controls by saccharide absorption technique assessing urinary recovery of orally administered sugars. We additionally measured LPS concentrations in 42 patients with decompensated heart failure and after recompensation.Results: CHF patients had a 54% reduction of active carrier-mediated intestinal transport compared to controls (p