Focused ultrasound thalamotomy for tremor treatment impacts the cerebello-thalamo-cortical network.
Focused ultrasound thalamotomy for tremor treatment impacts the cerebello-thalamo-cortical network.
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DOI：
10.1038/s41531-023-00543-8
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发表时间：
2023-06-15
影响因子：
8.7
通讯作者：
Wang, Meiyun
中科院分区：
文献类型：
--
作者：
Dahmani, Louisa;Bai, Yan;Li, Meiling;Ren, Jianxun;Shen, Lunhao;Ma, Jianjun;Li, Haiyang;Wei, Wei;Li, Pengyu;Wang, Danhong;Du, Lei;Cui, Weigang;Liu, Hesheng;Wang, Meiyun
高强度磁共振引导聚焦超声（MRgFUS）是一种最新的非侵入性治疗药物抵抗性震颤的方法。我们使用MRgFUS在13例震颤显性帕金森病或特发性震颤患者的丘脑腹侧中间核（VIM）中产生小病变，VIM是小脑-丘脑-皮质震颤网络的重要节点。目标手的震颤明显减轻（t(12) = 7.21, p < 0.001，双尾），这与大脑手区与小脑的功能重组密切相关（r = 0.91, p < 0.001，单尾）。这种重组可能反映了一个正常化的过程，因为在治疗后，患者的手小脑连通性与匹配的健康对照组（n = 48）之间的相似性有增加的趋势。相比之下，腹侧注意网络、背侧注意网络、默认网络和额顶叶网络的控制区域与震颤减轻没有关联，也没有正常化。更广泛地说，在属于运动、边缘、视觉和背侧注意网络的区域观察到功能连通性的变化，这些区域与与病变目标相连的区域很大程度上重叠。我们的研究结果表明，MRgFUS是一种高效的治疗震颤的方法，VIM的损伤可能导致小脑-丘脑-皮层震颤网络的重组。
High-intensity Magnetic Resonance-guided Focused Ultrasound (MRgFUS) is a recent, non-invasive line of treatment for medication-resistant tremor. We used MRgFUS to produce small lesions in the thalamic ventral intermediate nucleus (VIM), an important node in the cerebello-thalamo-cortical tremor network, in 13 patients with tremor-dominant Parkinson’s disease or essential tremor. Significant tremor alleviation in the target hand ensued (t(12) = 7.21, p < 0.001, two-tailed), which was strongly associated with the functional reorganization of the brain’s hand region with the cerebellum (r = 0.91, p < 0.001, one-tailed). This reorganization potentially reflected a process of normalization, as there was a trend of increase in similarity between the hand cerebellar connectivity of the patients and that of a matched, healthy control group (n = 48) after treatment. Control regions in the ventral attention, dorsal attention, default, and frontoparietal networks, in comparison, exhibited no association with tremor alleviation and no normalization. More broadly, changes in functional connectivity were observed in regions belonging to the motor, limbic, visual, and dorsal attention networks, largely overlapping with regions connected to the lesion targets. Our results indicate that MRgFUS is a highly efficient treatment for tremor, and that lesioning the VIM may result in the reorganization of the cerebello-thalamo-cortical tremor network.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
--
作者：
Bronstein JM;Tagliati M;Alterman RL;Lozano AM;Volkmann J;Stefani A;Horak FB;Okun MS;Foote KD;Krack P;Pahwa R;Henderson JM;Hariz MI;Bakay RA;Rezai A;Marks WJ Jr;Moro E;Vitek JL;Weaver FM;Gross RE;DeLong MR
通讯作者：
DeLong MR
影响因子：
158.5
作者：
Elias, W. Jeffrey;Huss, Diane;Wintermark, Max
通讯作者：
Wintermark, Max
影响因子：
11.2
作者：
Chang, Jin Woo;Park, Chang Kyu;Elias, W. Jeffrey
通讯作者：
Elias, W. Jeffrey
影响因子：
1.8
作者：
Gallay, Marc N.;Moser, David;Jeanmonod, Daniel
通讯作者：
Jeanmonod, Daniel