CHRONIC POST-WEANING LEAD-EXPOSURE AND RESPONSE DURATION PERFORMANCE
CHRONIC POST-WEANING LEAD-EXPOSURE AND RESPONSE DURATION PERFORMANCE
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DOI：
10.1016/0041-008x(81)90137-x
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发表时间：
1981-01-01
影响因子：
3.8
通讯作者：
THOMPSON, T
中科院分区：
文献类型：
--
作者：
CORYSLECHTA, DA;BISSEN, ST;THOMPSON, T
雄性断奶大鼠（5日龄）开始接受蒸馏水中0、100或300 ppm醋酸铅的慢性暴露方案。它们在55日龄时被训练按下杠杆以获得食物奖励。施加的最小响应持续时间的差分强化的时间表，其中只有杠杆按压持续时间大于或等于所需的持续时间之后，由食物介绍。在这些条件下，对照动物的反应持续时间接近时间表的要求;铅治疗缩短反应持续时间。接受治疗的大鼠在开始反应之前也会停顿更长时间。给药组之间的差异不明显。个体差异的易感性铅诱导的行为变化。一些给药动物的疗程间变异性大于对照组。即使当添加音调以发出所需持续时间已经过去的信号时，某些处理的大鼠也未能显示出与时间表要求一致的模态反应持续时间值。以前没有报道过通过外部刺激控制来改善铅处理大鼠的表现。
Male weanling rats (5 day old) were started on a chronic exposure regimen of 0, 100, or 300 ppm lead acetate in distilled water. They were trained to press a lever for food reward at 55 days of age. A schedule of differential reinforcement of minimum response duration was imposed, in which only lever press durations greater than or equal to a required duration were followed by food presentation. Under these conditions, response durations of control animals approximated schedule requirements; Pb treatment shortened response durations. Treated rats also paused for longer periods before initiating responses. Differences between the treated groups were not apparent. Individual differences were observed in susceptibility to Pb-induced behavioral changes. Some treated animals showed greater session-to-session variability than did controls. Even when a tone was added to signal that the required duration had elapsed, certain treated rats failed to show modal response duration values consistent with the schedule requirement. Failure to improve performance of Pb-treated rats by external stimulus control had not previously been reported.