Regulation by chronic drug administration of neuronal and cardiac calcium channel, beta-adrenoceptor and muscarinic receptor levels.
Regulation by chronic drug administration of neuronal and cardiac calcium channel, beta-adrenoceptor and muscarinic receptor levels.
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长期给药对神经元和心脏钙通道、β-肾上腺素受体和毒蕈碱受体水平的调节。
DOI：
10.1016/0006-2952(88)90135-9
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发表时间：
1988
影响因子：
5.8
通讯作者：
Triggle,DJ
中科院分区：
文献类型：
--
作者：
Gengo,P;Skattebøl,A;Moran,JF;Gallant,S;Hawthorn,M;Triggle,DJ
Chronic administration of atropine (40–100 mg/kg, 23 days) produced a 29–33% increase in muscarinic receptors, measured by [3H]quinuclidinyl benzilate binding, in rat brain. Diisopropyl phosphorofluoridate (0.9 mg/kg, 14 days) produced a 35% decrease in muscarinic receptors. Propranolol administration (800 μg/kg/hr, 10 days) increased beta-adrenoceptors, measured by [3H]dihydroalprenolol binding, by 69 and 50% in brain and heart respectively. Isoproterenol administration (800 μg/kg/hr, 10 days) produced a 50% reduction in cardiac beta-adrenoceptors but did not alter brain receptors. These drug treatments were without effect on binding of the Ca2+channel ligands, [3H]nimodipine and [3H]nitrendipine, to brain or heart respectively. However, chronic administration of nifedipine for 20 days (36 and 360 μg/kg/hr) did produce down-regulation of both cardiac and neuronal Ca2+channels and a similar down-regulation of beta-adrenoceptors. Co-regulation of Ca2+channels and neurotransmitter receptors may occur but may not be an automatic consequence of either receptor or channel regulation.
