Antipyrine metabolite formation in children in the acute phase of malnutrition and after recovery.
Antipyrine metabolite formation in children in the acute phase of malnutrition and after recovery.
复制标题
儿童营养不良急性期和恢复后的安替比林代谢物形成。
DOI：
10.1111/j.1365-2125.1980.tb01772.x
复制
发表时间：
1980
影响因子：
3.4
通讯作者：
D. Breimer
中科院分区：
文献类型：
--
作者：
N. Buchanan;M. Davis;M. Danhof;D. Breimer
1.测定5例营养不良急性期和恢复期儿童血浆安替比林清除率和尿安替比林及其主要代谢产物4-羟基安替比林、去甲安替比林、3-羟甲基安替比林和3-羧基安替比林的排泄量。并与3例正常儿童进行比较。2.营养康复后安替比林清除量由0.65±0.14mlmin~(-1)kg~(-1)增至1.07±0.20mlmin~(-1)kg~(-1)。3.4-羟基安替比林的尿量从6.1+/-4.5增加到14.7+/-5.9%，去甲安替比林从8.8+/-5.7增加到14.3+/-5.4，3-羟甲基-安替比林从11.8+/-8.3增加到20.5+/-5.6%(占剂量/24小时尿的百分比)。安替比林的排泄量从5.2+/-3.7%降至2.7+/-0.9%剂量。代谢物分布(不同代谢物排泄量之间的比率)没有显著差异。4.营养不良降低了安替比林的代谢速率，但对三种氧化途径的影响不大。
1. The plasma elimination rate of antipyrine and the urinary excretion of antipyrine and its primary metabolites 4-hydroxy-antipyrine, norantipyrine, 3-hydroxymethyl-antipyrine and 3-carboxyantipyrine were measured in five children in the acute phase of malnutrition and after recovery. The results were compared with those obtained in 3 normal children. 2. Upon nutritional rehabilitation antipyrine clearance increased from 0.65 +/- 0.14 ml min-1 kg-1 to 1.07 +/- 0.20 ml min-1 kg-1. 3. The urinary excretion of 4-hydroxy-antipyrine increased from 6.1 +/- 4.5 to 14.7 +/- 5.9%, norantipyrine from 8.8 +/- 5.7 to 14.3 +/- 5.4 and 3-hydroxy-methyl-antipyrine from 11.8 +/- 8.3 to 20.5 +/- 5.6% (% of dose/24h urine). Excretion of unchanged antipyrine decreased from 5.2 +/- 3.7 to 2.7 +/- 0.9% dose. The metabolite profile (ratio between the amounts of the various metabolites excreted) was not significantly different. 4. It is concluded that malnutrition decreases the rate of antipyrine metabolism, but it does not affect the three oxidative pathways differently.