Synthesis and anti-HCV activity of a new 2′-deoxy-2′-fluoro-2′-C-methyl nucleoside analogue

Synthesis and anti-HCV activity of a new 2′-deoxy-2′-fluoro-2′-C-methyl nucleoside analogue
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DOI:
10.1016/j.bmcl.2010.10.076
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发表时间:
2010-12-15
影响因子:
2.7
通讯作者:
Chang, Junbiao
Chang, Junbiao
中科院分区:
医学4区
文献类型:
--
作者:
Hu, Weidong;Wang, Ping'an;Chang, Junbiao

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2'-Deoxy-2'-fluoro-2'-C-methyl nucleoside analogue 4 was designed and synthesized. Initial biological studies indicated that this compound showed promising activity against HCV replication. (C) 2010 Elsevier Ltd. All rights reserved.