Human autoantibodies against HD1/plectin in paraneoplastic pemphigus.
Human autoantibodies against HD1/plectin in paraneoplastic pemphigus.
复制标题
副肿瘤性天疱疮中针对 HD1/凝集素的人类自身抗体。
DOI：
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发表时间：
1999
影响因子：
6.5
通讯作者：
Masayuki Amagai
中科院分区：
文献类型：
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作者：
Charlotte Proby;Y. Fujii;K. Owaribe;T. Nishikawa;Masayuki Amagai
副肿瘤性天疱疮（PNP）是一种自身免疫性水疱性疾病，发生与潜在的肿瘤。PNP患者产生针对多种抗原的特征性自身抗体，大多数被鉴定为细胞质蛋白质的斑蛋白家族的成员（桥斑蛋白I和II、大疱性类天疱疮抗原I、包斑蛋白和周斑蛋白）。HD 1/plectin是斑蛋白家族的另一个成员，以前在特征性PNP抗原复合物中未检测到，这可能与其大尺寸（分子量约500 kDa）相关的实际困难有关。在这项研究中，免疫沉淀和免疫印迹的组合被用来证明HD 1/plectin也被PNP患者的血清所识别。16例PNP血清中有13例HD 1/plectin阳性，而43例对照血清（11例寻常型天疱疮，11例落叶型天疱疮，11例大疱性类天疱疮和10例正常人）中无一例HD 1/plectin阳性。结合我们最近的发现，桥粒芯糖蛋白3和桥粒芯糖蛋白1是PNP中的细胞表面靶抗原，这一证明作为PNP中抗原复合物的另一组分的凝集素/HD 1证实PNP是针对桥粒芯糖蛋白和斑块蛋白家族分子的自身免疫性疾病。
Paraneoplastic pemphigus (PNP) is an autoimmune blistering disease that occurs in association with underlying neoplasms. PNP patients develop characteristic autoantibodies directed against multiple antigens, mostly identified as members of the plakin family of cytoplasmic proteins (desmoplakin I and II, bullous pemphigoid antigen I, envoplakin, and periplakin). HD1/plectin, another member of the plakin family, has not previously been detected in the characteristic PNP antigen complex, which may relate to practical difficulties associated with its large size (molecular weight approximately 500 kDa). In this study, a combination of immunoprecipitation and immunoblot is used to demonstrate that HD1/plectin is also recognized by sera from PNP patients. Thirteen of 16 PNP sera tested were positive for HD1/plectin compared with none of 43 control sera (11 pemphigus vulgaris, 11 pemphigus foliaceus, 11 bullous pemphigoid, and 10 normal individuals). Combined with our recent finding that desmoglein 3 and desmoglein 1 are cell surface target antigens in PNP, this demonstration of plectin/HD1 as another component of the antigen complex in PNP confirms that PNP is an autoimmune disease against desmoglein and plakin family molecules.
DOI：
10.1016/s0141-8130(05)80004-2
发表时间：
1992-06-01
影响因子：
8.2
作者：
GREEN, KJ;VIRATA, MLA;PARRY, DAD
通讯作者：
PARRY, DAD
影响因子：
4
作者：
B. Angst;L. A. Nilles;K. J. Green
通讯作者：
B. Angst;L. A. Nilles;K. J. Green
自体骨髓移植后支气管上皮内出现自身抗体沉积的副肿瘤性天疱疮。
DOI：
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发表时间：
1992
期刊：
JAMA : the journal of the American Medical Association
影响因子：
--
作者：
Fullerton,SH;Woodley,DT;Smoller,BR;Anhalt,GJ
通讯作者：
Anhalt,GJ