Studies of a deuterium isotope effect in carcinogenesis by N-nitroso-N-alkylurethanes in rats.
Studies of a deuterium isotope effect in carcinogenesis by N-nitroso-N-alkylurethanes in rats.
复制标题
N-亚硝基-N-烷基氨基甲酸酯在大鼠体内致癌作用中氘同位素效应的研究。
DOI：
10.1016/0304-3835(82)90007-6
复制
发表时间：
1982
期刊：
影响因子：
9.7
通讯作者：
M. D. Reuber
中科院分区：
文献类型：
--
作者：
W. Lijinsky;M. D. Reuber
Nitroso-N-methylurethane and nitroso-N-ethylurethane were administered to groups of 20 female F344 rats in corn oil solution by gavage. Each rat received once a week 0.2 ml of solution containing 7 mg/ml or 1.75 mg/ml of the methyl compound or 8 mg/ml or 2 mg/ml of the ethyl compound for 20 weeks. In parallel with these treatments additional groups of rats were given equimolar dose of nitrosomethylurethane and nitrosoethylurethane fully labeled with deuterium in the N-alkyl groups. All animals were allowed to die naturally. The total doses received by the rats were 0.2 mmol at the higher concentration and 0.05 mmol at the lower concentration. Almost all of the treated rats died with papillomas and carcinomas of the forestomach (non-glandular stomach), and the other induced tumors of significance were carcinomas and papillomas of the esophagus in rats given the 7 mg/ml dose of nitrosomethylurethane, both labeled and unlabeled. There was no significant difference in tumor incidence or rate of mortality from tumors that would indicate a difference in carcinogenic effectiveness between the nitrosoalkylurethanes and their deuterium-labeled counterparts. Apart from the esophageal tumors induced only by nitrosomethylurethane at the higher dose, there was no significant difference in carcinogenic effectiveness between the methyl and ethyl nitrosourethanes.
