Influence of malocclusion on the development of masticatory function and mandibular growth
Influence of malocclusion on the development of masticatory function and mandibular growth
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DOI：
10.2319/083012-698.1
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发表时间：
2013-09-01
影响因子：
3.4
通讯作者：
Yoshida, Noriaki
中科院分区：
文献类型：
--
作者：
Nakamura, Aya;Zeredo, Jorge L.;Yoshida, Noriaki
目的：验证错牙合改变咀嚼功能的适当获得和下颌骨正常生长的假设。材料与方法：18只Jcl：ICR小鼠分为两组。在一组中，我们使用咬合引导装置横向移动下颌骨，在 5 周龄时形成后牙反。另一组作为对照组。 10周后，在咀嚼过程中同时记录三维下颌运动和肌肉活动。在体内获得显微计算机断层扫描，以评估下颌骨的形态变化。结果：（1）矢状面的下颌运动模式显示，错牙合组在晚闭合阶段（动力阶段）的前后偏移显着减少。 (2)肌电图显示咬合不正组咬肌活动明显减少。 (3)与正常小鼠相比，错牙合小鼠的髁突宽度和下颌骨矿物质密度(BMD)显着降低。结论：这些研究结果表明，错牙合畸形阻碍了咀嚼模式的优化和适当咀嚼功能的获得。下颌骨机械负荷的改变可能会导致髁突宽度和下颌骨骨密度显着减小。
Objective: To verify the hypothesis that appropriate acquisition of masticatory function and normal growth of the mandible are modified by malocclusion.Materials and Methods: Eighteen Jcl:ICR mice were divided into two groups. In one group we shifted the mandible laterally using an occlusal guidance appliance, creating a posterior crossbite at 5 weeks of age. The other group served as control. After 10 weeks, three-dimensional jaw movements and muscle activities were recorded simultaneously during mastication. Microcomputed tomography scans were obtained in vivo to evaluate morphometric changes in the mandible.Results: (1) The jaw movement pattern in the sagittal plane showed significantly less anteroposterior excursion in the malocclusion group during the late-closing phase (power phase). (2) Electromyography showed significantly less masseter activity in the Malocclusion group. (3) The condylar width and mandibular bone mineral density (BMD) were significantly reduced in the malocclusion mice compared to the normal mice.Conclusions: These findings suggest that optimization of the chewing pattern and acquisition of appropriate masticatory function is impeded by malocclusion. Altered mechanical loading to the mandible may cause significant reduction of condylar width and mandibular BMD.