Cholesterol succinyl chitosan anchored liposomes: preparation, characterization, physical stability, and drug release behavior
Cholesterol succinyl chitosan anchored liposomes: preparation, characterization, physical stability, and drug release behavior
复制标题
胆固醇琥珀酰壳聚糖锚定脂质体：制备、表征、物理稳定性和药物释放行为
DOI：
10.1016/j.nano.2009.09.005
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发表时间：
2010-06-01
影响因子：
5.4
通讯作者：
Zhang, Qiqing
中科院分区：
文献类型：
--
作者：
Wang, Yinsong;Tu, Shaoli;Zhang, Qiqing
本研究的目的是制备胆固醇琥珀酰壳聚糖锚定脂质体，并考察其性质、物理稳定性和体外释药行为。合成了三种具有不同胆固醇取代度（DS）的胆固醇琥珀酰壳聚糖（CHCS）缀合物，并作为锚定材料，通过孵育法包被在脂质体表面。CAL几乎是球形的，具有典型的壳-核结构。与普通脂质体和壳聚糖包覆的脂质体（CCL）相比，CAL在4 +/- 2 ℃和25 +/- 2 ℃下储存后具有更大的尺寸、更高的zeta电位和更好的物理稳定性。作为模型药物，Epiraldehyde被有效地装载到CAL中，并且在磷酸盐缓冲溶液（pH 7.4）和1%（vol/vol）含水胎牛血清中表现出比普通脂质体和CCLs.From Clinical Editor更持续的释放：胆固醇琥珀酰壳聚糖锚定脂质体（CAL）作为递送载体，其特征在于在这项工作中，包括它们的物理稳定性和体外药物释放行为。以表阿霉素为模型药物，将其有效地负载于CAL中，并在磷酸盐缓冲液（PBS，pH 7.4）和1%（V/V）胎牛血清（FBS）中均表现出缓释行为。(C)2010年爱思唯尔公司All rights reserved.
The purpose of this study was to prepare cholesterol succinyl chitosan anchored liposomes (CALs) and to investigate their characterization, physical stability, and drug release behavior in vitro. Three cholesterol succinyl chitosan (CHCS) conjugates with different substitution degrees (DS) of the cholesterol moiety were synthesized and used as the anchoring materials to coating on the liposome surface by the incubation method. CALs were almost spherical and had a classic shell-core structure. Compared with plain liposomes and chitosan-coated liposomes (CCLs), CALs had larger sizes, higher zeta potentials, and better physical stability after storage at 4 +/- 2 degrees C and 25 +/- 2 degrees C. Epirubicin, as a model drug, was effectively loaded into CALs and exhibited the more sustained release in both phosphate buffer solution (pH 7.4) and 1% (vol/vol) aqueous fetal bovine serum compared to plain liposomes and CCLs.From the Clinical Editor: Cholesterol succinyl chitosan anchored liposomes (CAL) as delivery vehicles are characterized in this work, including their physical stability and drug release behavior in vitro. Epirubicin as a model drug, was effectively loaded into CALs, and exhibited sustained release behavior both in phosphate buffer solution (PBS, pH 7.4) and 1% (V/V) aqueous fetal bovine serum (FBS). (C) 2010 Elsevier Inc. All rights reserved.