Spirotoamides A and B, novel 6,6-spiroacetal polyketides isolated from a microbial metabolite fraction library
Spirotoamides A and B, novel 6,6-spiroacetal polyketides isolated from a microbial metabolite fraction library
复制标题
DOI：
10.1038/ja.2011.121
复制
发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
T. Nogawa;Shunji Takahashi;Akiko Okano;M. Kawatani;M. Uramoto;Tamio Saito;H. Osada
中科院分区：
文献类型：
--
作者：
T. Nogawa;Shunji Takahashi;Akiko Okano;M. Kawatani;M. Uramoto;Tamio Saito;H. Osada
从灰色产色链霉菌JC 82 -1223的代谢产物库中，通过光谱数据库检索，筛选结构独特的化合物，得到两个新的6，6-螺缩醛聚酮化合物：螺酰胺A（1）和B（2）。利用系统分离方法构建馏分库，以有效地从微生物来源如放线菌和真菌中发现新的代谢产物。化合物1和2的结构经2D-NMR和质谱鉴定。它们属于一类聚酮化合物，并且含有6，6-螺缩醛核心结构和甲酰胺基团。文中讨论了1和2的生物合成途径。
Two new 6, 6-spiroacetal polyketides, spirotoamides A (1) and B (2), were isolated from a microbial metabolite fraction library of Streptomyces griseochromogenes JC82-1223 by screening of structurally unique compounds based on a search of spectral database. The fraction library was constructed using a systematic separation method to efficiently discover new metabolites from microbial sources such as actinomycetes and fungi. The structures of 1 and 2 were elucidated by 2D-NMR and mass spectrometric measurements. They belong to a class of polyketides, and contain a 6, 6-spiroacetal core structure and a carboxamide group. The biosynthetic pathway of 1 and 2 is discussed in the text.