Gallium nitride is biocompatible and non-toxic before and after functionalization with peptides
Gallium nitride is biocompatible and non-toxic before and after functionalization with peptides
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DOI：
10.1016/j.actbio.2011.09.038
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发表时间：
2012-02-01
影响因子：
9.7
通讯作者：
Ivanisevic, Albena
中科院分区：
文献类型：
--
作者：
Jewett, Scott A.;Makowski, Matthew S.;Ivanisevic, Albena
半导体材料的毒性会严重阻碍其在体内和体外的应用。氮化镓（GaN）是一种具有优异化学稳定性的材料。这项工作表明，功能化和蚀刻的GaN表面在水环境中是稳定的，即使在过氧化氢存在的情况下，溶液中浸出的Ga也可以忽略不计。此外，细胞培养中的GaN表面不会干扰附近细胞的生长，并且与蚀刻的硅表面相比，蚀刻的GaN促进了细胞的粘附。模型肽“IKVAV”共价附着在GaN和硅表面，增加了PC12细胞的粘附性。终止肽的氮化镓促进了更大的细胞扩散和神经突的延伸。结果表明，肽修饰的GaN是一种生物相容性和无毒的材料，可用于探测与神经界面相关的化学和电刺激。(C) 2011材料学报Elsevier Ltd.出版。版权所有。
The toxicity of semiconductor materials can significantly hinder their use for in vitro and in vivo applications. Gallium nitride (GaN) is a material with remarkable properties, including excellent chemical stability. This work demonstrated that functionalized and etched GaN surfaces were stable in aqueous environments and leached a negligible amount of Ga in solution even in the presence of hydrogen peroxide. Also, GaN surfaces in cell culture did not interfere with nearby cell growth, and etched GaN promoted the adhesion of cells compared to etched silicon surfaces. A model peptide, "IKVAV", covalently attached to GaN and silicon surfaces increased the adhesion of PC12 cells. Peptide terminated GaN promoted greater cell spreading and extension of neurites. The results suggest that peptide modified GaN is a biocompatible and non-toxic material that can be used to probe chemical and electrical stimuli associated with neural interfaces. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.