Missing the mark? Exploratory analysis of the 10-year-old cutoff as an independent marker of high-risk disease in pediatric B-ALL.
Missing the mark? Exploratory analysis of the 10-year-old cutoff as an independent marker of high-risk disease in pediatric B-ALL.
复制标题
DOI：
10.1002/pbc.30825
复制
发表时间：
2023-12
影响因子：
3.2
通讯作者：
Paul E George;Nicholas Degroote;Michaela Henderson;Katherine Jordan;Christiana Ziworitin-Ogola;S. Castellino;Tamara P. Miller
中科院分区：
文献类型：
--
作者：
Paul E George;Nicholas Degroote;Michaela Henderson;Katherine Jordan;Christiana Ziworitin-Ogola;S. Castellino;Tamara P. Miller
这项单中心、回顾性研究在153例B细胞急性淋巴细胞白血病儿童中评价了年龄作为复发性/难治性疾病和/或死亡的风险因素。研究样本包括接近10岁高危疾病临界年龄（诊断时6.0 - 13.9岁）且无其他高危特征（高白色细胞计数、不利的细胞遗传学）的儿童。与按照标准风险方案开始治疗的6.0 - 9.9岁儿童相比，按照高风险方案治疗的10.0 - 13.9岁儿童的结局并不差。这项研究表明，在细胞遗传学时代，10岁的年龄阈值可能不是一个独立的预后指标。需要进行多中心分析。
This single‐center, retrospective study evaluated age as a risk factor for relapsed/refractory disease and/or death in 153 children with B‐cell acute lymphoblastic leukemia. The study sample included children near the 10‐year age cutoff for high‐risk disease (6.0‐13.9 years at diagnosis) and without other high‐risk features (high white cell count, unfavorable cytogenetics). Children 10.0‐13.9 years treated per high‐risk protocols did not have inferior outcomes compared with children aged 6.0‐9.9 years initiating treatment per standard‐risk protocols. The study indicates that, in the era of cytogenetics, an age threshold of 10 years might not be an independent prognostic marker. Multicenter analyses are needed.