GFAP EXPRESSION IN LUMBAR SPINAL-CORD OF NAIVE AND NEUROPATHIC RATS TREATED WITH MK-801
GFAP EXPRESSION IN LUMBAR SPINAL-CORD OF NAIVE AND NEUROPATHIC RATS TREATED WITH MK-801
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DOI：
10.1006/exnr.1994.1165
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发表时间：
1994-10-01
影响因子：
5.3
通讯作者：
CARLTON, SM
中科院分区：
文献类型：
--
作者：
GARRISON, CJ;DOUGHERTY, PM;CARLTON, SM
本研究的目的是确定神经胶质原纤维酸性蛋白（GFAP）的基线表达和慢性坐骨神经收缩引起的GFAP表达的增加是否被特异性n -甲基- d -天冬氨酸（NMDA）受体拮抗剂MK-801所改变。定量比较三组动物L4脊髓GFAP免疫组化染色密度的变化：(1)非神经病大鼠，(2)非药物治疗神经病大鼠，(3)MK-801治疗7天的神经病大鼠。结果表明，初始动物的基线GFAP染色密度依赖于NMDA受体活性，并且持续的NMDA依赖信号至少在一定程度上负责周围神经损伤后观察到的GFAP增加。(C) 1994学术出版社，Inc.
The objective of the present investigation was to determine if baseline glial fibrillary acidic protein (GFAP) expression and the increases in GFAP expression induced by chronic constriction of the sciatic nerve were modified by the specific N-methyl-D-aspartate (NMDA) receptor antagonist MK-801. Changes in immunohistochemical staining densities of GFAP within the L4 spinal cord were quantified and compared in three groups of animals: (1) nonneuropathic rats, (2) nondrug-treated neuropathic rats, and (3) neuropathic rats treated for 7 days with MK-801. The results indicate that baseline GFAP staining density in naive animals is dependent on NMDA receptor activity and that an ongoing NMDA-dependent signal is, at least in part, responsible for the increase in GFAP observed following-peripheral nerve injury. (C) 1994 Academic Press, Inc.