Treatment adherence mediates the relationship between HIV-related stigma and health-related quality of life
Treatment adherence mediates the relationship between HIV-related stigma and health-related quality of life
复制标题
治疗依从性介导艾滋病毒相关耻辱与健康相关生活质量之间的关系
作者：
D. U. Onu
艾滋病相关污名（HS）与艾滋病病毒/艾滋病患者健康相关的生活质量之间存在密切联系，但迄今为止，很少有研究探讨这种联系的中介。本研究探讨了抗逆转录病毒药物依从性（MA）的中介作用HS和HRQoL之间的关联。调查对象为969名艾滋病毒/艾滋病感染者（628名男性和341名女性，平均年龄= 35.55岁），均来自尼日利亚埃努古州和埃邦伊州的4家医院。数据收集使用艾滋病毒污名量表，Morisky医疗依从性量表，和患者报告的结果生活质量-艾滋病毒。使用SPSS的Hayes PROCESS宏分析数据，该宏使用基于回归的路径分析框架。结果显示，HS的各个维度（个性化的耻辱，披露关注，关注人们的态度和消极的自我形象）与MA呈负相关（分别为r =-0.16; p < .001，r =-0.13; p < .00，r =-0.22; p < .001和r =-0.21; p < .001）HRQoL。MA与HRQoL呈正相关（r = . 24; p < .001）。MA介导的HS-HRQoL相关性。这些研究结果表明，与艾滋病毒/艾滋病相关的耻辱感与积极的抗逆转录病毒疗法（ART）治疗方案的依从性差有关，这可能导致PLWH的健康状况和治疗结果不佳。这一发现可能有助于改善PLWH的HRQoL。
ABSTRACT There is a strong association between HIV-related stigma (HS) and health-related quality of life among people living with HIV/AIDS, yet few studies, to date, have examined mediators of this link. This study examined the mediating role of antiretroviral medication adherence (MA) on association between HS and HRQoL. Respondents were 969 people living with HIV/AIDS (PLWH) (628 males and 341 females, Mean age = 35.55, years), conveniently drawn from four hospital facilities in Enugu and Ebonyi States of Nigeria. Data were collected using HIV Stigma Scale, Morisky Medical Adherence Scale, and Patient Reported Outcome Quality of Life-HIV. Data were analysed using the Hayes PROCESS macro for SPSS which uses a regression-based, path-analytical framework. Results showed that HS across dimensions (personalised stigma, disclosure concern, concern about people’s attitude and negative self-image) were negatively associated with MA (r = −.16; p < .001, r = −.13; p < .00, r = −.22; p < .001 and r = −.21; p < .001, respectively) HRQoL. MA was positively associated with HRQoL (r = . 24; p < .001). MA mediated HS-HRQoL association. These findings suggest that stigma associated with HIV/AIDS is associated with poor adherence to active antiretroviral therapy (ART) treatment regimen, which can result in poor health and treatment outcome among PLWH. The findings may be helpful in improving HRQoL among PLWH.
影响因子：
4.9
作者：
Kalichman, Seth C.;Cherry, Chauncey;Kalichman, Moira O.
通讯作者：
Kalichman, Moira O.