Regio- and enantio-selective allylic alkylation catalysed by a chiral monophosphine-palladium complex
Regio- and enantio-selective allylic alkylation catalysed by a chiral monophosphine-palladium complex
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DOI：
10.1039/a700045f
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发表时间：
1997-03-21
影响因子：
4.9
通讯作者：
Uozumi, Y
中科院分区：
文献类型：
--
作者：
Hayashi, T;Kawatsura, M;Uozumi, Y
在与 (R)-2-二苯基膦基-2'-甲氧基-1,1'-联萘基 [(R)-MeO-MOP] 配位的钯催化剂存在下，外消旋 1-芳基丙-2-烯基乙酸酯 [ArCH(OAc)CH=CH2] 与甲基丙二酸二甲酯的烯醇钠进行烯丙基烷基化，以高支链选择性 (90%) 生成手性产物[ArC*H-(Nu)CH=CH2] 高达 87% ee。
Allylic alkylation of racemic 1-arylprop-2-enyl acetates [ArCH(OAc)CH=CH2] with the sodium enolate of dimethyl methylmalonate in the presence of a palladium catalyst coordinated with (R)-2-diphenylphosphino-2'-methoxyl-1,1'-binaphthyl [(R)-MeO-MOP] proceeds with high branch selectivity (90%) to give chiral products [ArC*H-(Nu)CH=CH2] of up to 87% ee.