Hyperbaric oxygen as an adjunctive therapy in treatment of malignancies, including brain tumours.
Hyperbaric oxygen as an adjunctive therapy in treatment of malignancies, including brain tumours.
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DOI：
10.1007/s12032-016-0814-0
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Matyja E
中科院分区：
文献类型：
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作者：
Stępień K;Ostrowski RP;Matyja E
高压氧（HBO）疗法被广泛用作主要与缺氧和/或缺血状况相关的各种病理状态的连续治疗。它还有望成为克服肿瘤组织缺氧区域缺氧问题的一种方法。在实体瘤的中心区域内发生局部缺氧是导致无效医疗的主要问题之一。然而，在抗癌治疗中，单独使用HBO的疗效有限，通常不单独使用。更多的时候，高压氧被用作辅助治疗沿着其他治疗方式，如放射和化学疗法。本综述概述了现有的数据有关的医疗使用HBO在癌症治疗中，特别侧重于使用HBO治疗脑肿瘤。我们的结论是，HBO的管理可以提供许多临床益处，在肿瘤的治疗，包括高度恶性胶质瘤的管理。在照射前立即使用，它是安全的，患者耐受性良好，引起罕见和有限的副作用。HBO/放射治疗方案的组合所获得的结果被证明是特别有利的相比，单独的放射治疗。HBO还可以增加某些药物的细胞抑制作用，这可能使标准化疗更有效。目前可用的数据支持进一步研究高压氧治疗恶性肿瘤的合法性。
Hyperbaric oxygen (HBO) therapy is widely used as an adjunctive treatment for various pathological states, predominantly related to hypoxic and/or ischaemic conditions. It also holds promise as an approach to overcoming the problem of oxygen deficiency in the poorly oxygenated regions of the neoplastic tissue. Occurrence of local hypoxia within the central areas of solid tumours is one of the major issues contributing to ineffective medical treatment. However, in anti-cancer therapy, HBO alone gives a limited curative effect and is typically not applied by itself. More often, HBO is used as an adjuvant treatment along with other therapeutic modalities, such as radio- and chemotherapy. This review outlines the existing data regarding the medical use of HBO in cancer treatment, with a particular focus on the use of HBO in the treatment of brain tumours. We conclude that the administration of HBO can provide many clinical benefits in the treatment of tumours, including management of highly malignant gliomas. Applied immediately before irradiation, it is safe and well tolerated by patients, causing rare and limited side effects. The results obtained with a combination of HBO/radiotherapy protocol proved to be especially favourable compared to radiation treatment alone. HBO can also increase the cytostatic effect of certain drugs, which may render standard chemotherapy more effective. The currently available data support the legitimacy of conducting further research on the use of HBO in the treatment of malignancies.