Emerging themes in SecA2-mediated protein export.
Emerging themes in SecA2-mediated protein export.
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DOI：
10.1038/nrmicro2874
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Braunstein M
中科院分区：
文献类型：
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作者：
Feltcher ME;Braunstein M
保守的一般分泌（Sec）途径在细菌中执行大多数蛋白质输出，并由必需的SecA atp酶提供动力。有趣的是，分枝杆菌和一些革兰氏阳性细菌具有两种SecA蛋白：SecA1和SecA2。在这些物种中，SecA1负责输出大部分蛋白质，而SecA2只输出一部分底物，并与毒力有关。然而，尽管关于规范SecA （SecA1）的知识体系令人印象深刻，但关于SecA2功能的了解却很少。在这里，我们回顾了目前对不同类型SecA2系统的理解，并概述了SecA2研究的未来方向。
The conserved general secretion (Sec) pathway carries out most protein export in bacteria and is powered by the essential SecA ATPase. Interestingly, mycobacteria and some Gram positive bacteria possess two SecA proteins: SecA1 and SecA2. In these species, SecA1 is responsible for exporting the majority of proteins whereas SecA2 exports only a subset of substrates and is implicated in virulence. However, despite the impressive body of knowledge on the canonical SecA (SecA1), less is known concerning SecA2 function. Here, we review our current understanding of the different types of SecA2 systems and outline future directions for SecA2 studies.