Mechanotransduction in cancer.
Mechanotransduction in cancer.
复制标题
DOI：
10.1016/j.coche.2016.01.011
复制
发表时间：
2016-02
影响因子：
6.6
通讯作者：
Janmey PA
中科院分区：
文献类型：
--
作者：
Chin L;Xia Y;Discher DE;Janmey PA
组织硬度在正常条件下受到严格控制，但会随着疾病而变化。在癌症中，肿瘤往往比周围未受累的组织更坚硬，而细胞本身则会软化。在过去的十年中，特别是在过去的几年中，有越来越多的证据表明，细胞外基质的硬度调节癌症和基质细胞的力学和功能，影响这些疾病的标志，如血管生成，迁移和转移。这篇综述简要总结了最近的研究，探讨癌细胞和纤维化相关的基质细胞如何响应ECM刚度，可能的传感附件和信号转导机制的参与，以及新的基板的出现-包括基板瘢痕样分形异质性-模拟体内的癌细胞的机械环境。
Tissue stiffness is tightly controlled under normal conditions, but changes with disease. In cancer, tumors often tend to be stiffer than the surrounding uninvolved tissue, yet the cells themselves soften. Within the past decade, and particularly in the last few years, there is increasing evidence that the stiffness of the extracellular matrix modulates cancer and stromal cell mechanics and function, influencing such disease hallmarks as angiogenesis, migration, and metastasis. This review briefly summarizes recent studies that investigate how cancer cells and fibrosis-relevant stromal cells respond to ECM stiffness, the possible sensing appendages and signaling mechanisms involved, and the emergence of novel substrates — including substrates with scar-like fractal heterogeneity — that mimic the in vivo mechanical environment of the cancer cell.