The effect of antenatal lifestyle advice for women who are overweight or obese on secondary measures of neonatal body composition: the LIMIT randomised trial
The effect of antenatal lifestyle advice for women who are overweight or obese on secondary measures of neonatal body composition: the LIMIT randomised trial
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DOI：
10.1111/1471-0528.13796
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发表时间：
2016-01-01
影响因子：
5.8
通讯作者：
Robinson, J. S.
中科院分区：
文献类型：
--
作者：
Dodd, J. M.;Deussen, A. R.;Robinson, J. S.
目的评价提供产前饮食和生活方式建议对新生儿人体测量的影响，并确定获得人体测量结果的观察者间差异。设计随机对照试验。设置南澳大都市阿德莱德的公立妇产医院。人群单胎妊娠10（+0）至20（+0）周的孕妇，方法将妇女随机分为生活方式建议组（由研究营养师和研究助理在怀孕期间进行全面的饮食和生活方式干预，包括饮食、锻炼和行为策略）或继续标准护理组。使用意向治疗principles.Main outcome measures次要结果的措施，试验包括评估婴儿的身体组成，使用体围和皮褶厚度测量（SFTM），体脂百分比，和生物阻抗分析的无脂肪mass.Results人体测量测量结果获得970名新生儿（488生活方式的建议组，和482标准护理组）。其中394例新生儿（生活方式建议组215例，标准护理组179例）也进行了生物阻抗分析。在体围测量、SFTM、体脂百分比、脂肪质量或去脂质量方面，接受生活方式建议的女性和接受标准护理的女性所生的新生儿之间没有统计学显著差异。SFTM的组内相关系数为中度至极好（0.55-0.88）。结论在超重或肥胖妇女所生的新生儿中，产前饮食和生活方式干预并不能改变人体测量的身体组成。
Objective To evaluate the effect of providing antenatal dietary and lifestyle advice on neonatal anthropometry, and to determine the inter-observer variability in obtaining anthropometric measurements.Design Randomised controlled trial.Setting Public maternity hospitals across metropolitan Adelaide, South Australia.Population Pregnant women with a singleton gestation between 10(+0) and 20(+0) weeks, and body mass index (BMI) = 25 kg/m(2).Methods Women were randomised to either Lifestyle Advice (comprehensive dietary and lifestyle intervention over the course of pregnancy including dietary, exercise and behavioural strategies, delivered by a research dietician and research assistants) or continued Standard Care. Analyses were conducted using intention-to-treat principles.Main outcome measures Secondary outcome measures for the trial included assessment of infant body composition using body circumference and skinfold thickness measurements (SFTM), percentage body fat, and bio-impedance analysis of fat-free mass.Results Anthropometric measurements were obtained from 970 neonates (488 Lifestyle Advice Group, and 482 Standard Care Group). In 394 of these neonates (215 Lifestyle Advice Group, and 179 Standard Care Group) bio-impedance analysis was also obtained. There were no statistically significant differences identified between those neonates born to women receiving Lifestyle Advice and those receiving Standard Care, in terms of body circumference measures, SFTM, percentage body fat, fat mass, or fat-free mass. The intra-class correlation coefficient for SFTM was moderate to excellent (0.55-0.88).Conclusions Among neonates born to women who are overweight or obese, anthropometric measures of body composition were not modified by an antenatal dietary and lifestyle intervention.Tweetable abstract Lifestyle advice in pregnancy does not modify body composition of infants of overweight and obese women.