Microtubule-targeting anticancer agents from marine natural substance.
Microtubule-targeting anticancer agents from marine natural substance.
复制标题
DOI：
10.2174/187152061403140207163402
复制
发表时间：
2014-02
影响因子：
2.8
通讯作者：
Zhiguo Liu;Pengfei Xu;Tao Wu;Wenbin Zeng
中科院分区：
文献类型：
--
作者：
Zhiguo Liu;Pengfei Xu;Tao Wu;Wenbin Zeng
由于恶性肿瘤发病率的增加和药物的多重耐药，迫切需要有效的新型治疗方法。天然产物及其衍生物历来是制药先导和治疗药物的来源。微管靶向化合物是对抗癌症最有希望的候选药物之一。特别是，海洋天然产物（MNPs）已经证明了作为抗癌剂的特殊效力和潜力。MNPs的药物发现为开发原创性抗癌药物提供了新的途径。本文综述了7类具有不同结构的典型MNPs。从不同的生物，包括无脊椎动物，藻类，真菌和细菌分离的生物活性海洋化合物也进行了讨论。
Effective novel therapeutics is urgently needed due to increasing incidence of malignant cancer and drug multi-resistance. Natural products and their derivatives have historically been a source of pharmaceutical leads and therapeutic drugs. Microtubule-targeting compounds are among the most promising candidates in the combat against cancer. In particular, marine natural products (MNPs) have demonstrated exceptional potency and potential as anticancer agents. Drug discovery from MNPs provides a new pathway to develop original anticancer agents. In this review, seven classes of typical MNPs with diverse structures are summarized. Bioactive marine compounds isolated from different organisms including invertebrate animals, algae, fungi and bacteria are also discussed.