Coordinate expression of hypothalamic pro-dynorphin and pro-vasopressin mRNAs with osmotic stimulation.
Coordinate expression of hypothalamic pro-dynorphin and pro-vasopressin mRNAs with osmotic stimulation.
复制标题
协调下丘脑强啡肽原和加压素原 mRNA 的表达与渗透刺激。
DOI：
10.1159/000124649
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发表时间：
1986
影响因子：
4.1
通讯作者：
Watson,SJ
中科院分区：
文献类型：
--
作者：
Sherman,TG;Civelli,O;Douglass,J;Herbert,E;Watson,SJ
强啡肽原和加压素前体衍生的肽共存于大鼠下丘脑向垂体后叶投射的大细胞神经元的神经分泌囊泡内。这些神经元的分泌活性可以使用已知增加血浆加压素水平的生理操作来刺激，例如脱水和盐负荷。随着慢性渗透性的挑战，强啡肽原和加压素原的mRNA的增加，在平行的视上和室旁核的下丘脑，但不是在nonmagnocellular视交叉上核细胞群投射在其他地方比神经叶。结果表明，一个例子的协调调节mRNA表达的共存肽在大脑内。
Peptides derived from pro-dynorphin and pro-vasopressin precursors coexist within neurosecretory vesicles of magnocellular neurons in the rat hypothalamus projecting to the posterior pituitary. The secretory activity of these neurons can be stimulated using physiological manipulations known to increase plasma vasopressin levels, such as dehydration and salt-loading. With chronic osmotic challenge, the mRNAs for both pro-dynorphin and pro-vasopressin increase in parallel in the supraoptic and paraventricular nuclei of the hypothalamus, but not within the nonmagnocellular suprachiasmatic nucleus cell groups projecting elsewhere than the neural lobe. The results indicate an example of coordinate regulation of mRNA expression for coexisting peptides within the brain.