prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2.
prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2.
复制标题
prICE：神经酰胺诱导的细胞凋亡和 Bcl-2 抑制作用的下游靶点。
DOI：
10.1042/bj3160025
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Obeid,LM
中科院分区：
文献类型：
--
作者：
Smyth,MJ;Perry,DK;Zhang,J;Poirier,GG;Hannun,YA;Obeid,LM
新的脂质第二信使，神经酰胺，通过激活蛋白酶prICE特异性诱导聚（ADP-核糖）聚合酶裂解。Bcl-2的过表达抑制了神经酰胺诱导的聚（ADP-核糖）聚合酶蛋白水解，并保护细胞免受神经酰胺诱导的死亡。这些数据提供了神经酰胺介导细胞凋亡的机制的第一个见解，并提出了一种机制，Bel-2保护细胞死亡。
The novel lipid second messenger, ceramide, specifically induced poly(ADP-ribose) polymerase cleavage through activation of the protease prICE. Over-expression of Bcl-2 inhibited ceramide-induced poly(ADP-ribose) polymerase proteolysis and protected cells from ceramide-induced death. These data provide the first insight into the mechanism by which ceramide mediates apoptosis and suggest a mechanism by which Bel-2 protects from cell death.