The Relationship Between Study Characteristics and the Prevalence of Medication-Related Hospitalizations A Literature Review and Novel Analysis
The Relationship Between Study Characteristics and the Prevalence of Medication-Related Hospitalizations A Literature Review and Novel Analysis
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DOI：
10.2165/11319030-000000000-00000
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发表时间：
2010-01-01
期刊：
影响因子：
4.2
通讯作者：
van den Bemt, Patricia M. L. A.
中科院分区：
文献类型：
--
作者：
Leendertse, Anne J.;Visser, Djurre;van den Bemt, Patricia M. L. A.
背景：关于药物相关住院的研究在研究背景、研究人群、结果和数据收集方法上有所不同。目的：探讨研究特征对药物相关住院率的影响。方法：通过结构化的文献检索，对检索到的研究按以下几个方面进行分类：(I)研究背景(例如，所有住院患者与仅急性住院患者)；(Ii)研究人群(例如，整个医院、研究病房(S)、选定人群和/或年龄组)；(Iii)与药物有关的问题的结果(例如，药物不良反应[ADR]与药物不良事件[ADE])；(Iv)数据收集方法(例如，医疗图表审查、自发报告或数据库研究)；以及(V)进行研究的大陆(仅针对所有急性入院的研究)。结果：95项研究分析了95项研究，报告的药物相关住院率从0.1%到54%不等。在检查所有入院情况的研究中发现，与仅检查急性入院情况的研究相比，患病率更高。此外，老年人群的患病率高于儿童。正如预期的那样，在检查ADE的研究中也发现了比只检查ADR的研究更高的患病率。在数据收集方法方面，病历筛选导致与药物相关的住院发生率高于数据库方法或自发报告。欧洲的联合研究显示，与研究中的其他大洲相比，与药物相关的住院率较低。讨论：报告的与药物相关的住院率与环境(所有入院或仅急性入院)、研究人群(整个医院、特定病房、选定的人群和年龄组)、结果(ADR/ADE)、数据收集方法和研究进行的大陆有关。结论：使用国家住院数据进行推断和汇集国际研究确定的流行率应非常谨慎。
Background: Studies on medication-related hospitalizations differ in study setting, studied population, outcome, and method of data collection. Thus, extrapolations based on a meta-analysis of unselected studies may be biased.Objective: To explore the influence of study characteristics on the prevalence of medication-related hospitalizations.Methods: After a structured literature search, the retrieved studies were categorized based on the following aspects: (i) study setting (e.g. all hospital admissions vs only acute hospital admissions); (ii) study population (e.g. an entire hospital, study ward(s), selected population and/or age group); (iii) outcome of medication-related problem (e.g. adverse drug reaction [ADR] vs adverse drug event [ADE]); (iv) method of data collection (e.g. medical chart review, spontaneous reporting or database research); and (v) continent in which the study took place (only for studies looking at all acute admissions). We then examined the relationship between these factors and reported prevalence of medication-related hospital admissions.Results: Ninety-five studies were analysed, with a range of reported prevalence of medication-related hospitalizations from 0.1% to 54%. Higher prevalences were found in the studies examining all hospital admissions than in the studies examining only acute hospital admissions. In addition, higher prevalences were found in the elderly population than in children. As would be expected, higher prevalences were also found in studies examining ADEs than in studies examining only ADRs. With respect to the method of data collection, medical chart screening resulted in higher prevalences of medication-related hospitalizations than database methods or spontaneous reporting. Combined studies in Europe show lower prevalences of medication-related hospital admissions than in other continents included in the study.Discussion: The reported prevalence of medication-related hospital admissions varies as a function of the setting (all admissions or only acute admissions), studied population (entire hospital, specific wards, selected population and age group), outcome (ADR/ADE), the method of data collection and the continent in which the study is performed.Conclusion: Extrapolation using national hospital admission data and the prevalence identified by pooling international studies should be carried out with great caution.