Bright light shows promise in improving sleep, depression, and quality of life in women with breast cancer during chemotherapy: findings of a pilot study.
Bright light shows promise in improving sleep, depression, and quality of life in women with breast cancer during chemotherapy: findings of a pilot study.
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DOI：
10.1080/07420528.2021.1871914
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发表时间：
2021-05
影响因子：
2.8
通讯作者：
Chen L
中科院分区：
文献类型：
--
作者：
Wu HS;Davis JE;Chen L
化疗期间与睡眠和疲劳相关的症状很突出。这项试点研究的目的是检查强光对接受化疗的 I-III 期乳腺癌女性的睡眠中断、疲劳、白天嗜睡、抑郁和生活质量 (QOL) 的影响。在这项 2 组随机对照试验 (NCT02658708) 中，参与者被随机分配接受 12,000 勒克斯的蓝绿光（实验）或 5 勒克斯的暗红光（对照）。光疗是在家里使用光面罩自行进行的。两组患者在第二个化疗周期后连续 21 天每天接受 30 分钟的光疗。睡眠质量、疲劳、白天嗜睡、抑郁和生活质量均由患者自我报告，并在化疗开始前（基线）和光照干预后（测试后）通过动态多导睡眠图监测夜间睡眠。在测试后控制测试前分数时评估相对变化。测试后，实验组自我报告的睡眠潜伏期明显短于对照组（10 分钟与 20 分钟，p=0.045），这与多导睡眠监测结果（14 分钟与 63 分钟）一致。多导睡眠图还显示，与对照组相比，实验组的总睡眠时间更长（467 分钟 vs. 315 分钟），睡眠效率更高（74% vs. 58%）。接受强光照射的参与者的抑郁程度相对降低了 30%，而对照组的抑郁程度则增加了 24%。实验组报告的症状强度增加明显少于对照组（33% vs. 166%）。这些发现表明，明亮的光线可能会改善睡眠质量和抑郁症，并减轻前三个化疗周期期间症状恶化的强度。然而，亮光的特征，例如治疗持续时间、频率以及与化疗相关的时间安排需要进一步研究。
Sleep and fatigue-associated symptoms are prominent during chemotherapy. The purpose of this pilot study was to examine bright light effects on sleep disruption, fatigue, daytime sleepiness, depression, and quality of life (QOL) in women with stage I-III breast cancer undergoing chemotherapy. In this 2-group randomized controlled trial (NCT02658708), participants were randomized to receive either blue-green light of 12,000 lux (experimental) or dim red light of 5 lux (control). Light therapy was self-administered using a light visor cap at home. Both groups received 30-minute daily light therapy for 21 consecutive days following the 2nd cycle of chemotherapy. Sleep quality, fatigue, daytime sleepiness, depression, and QOL were self-reported, and nocturnal sleep was monitored by ambulatory polysomnography before the initiation of chemotherapy (baseline) and following the light intervention (post-test). Relative change was assessed at post-test controlling for pretest scores. At post-test, the experimental group self-reported significantly shorter sleep latency than controls (10 vs. 20 min, p=.045) consistent with polysomnography findings (14 vs. 63 min). Polysomnography also revealed longer total sleep time (467 vs. 315 min) and higher sleep efficiency (74% vs. 58%) in experimental vs. controls. Participants receiving bright light experienced a 30% relative decrease in depression, while there was a 24% increase in the controls. The experimental group reported substantially fewer increases in symptom intensity than controls (33% vs. 166%). These findings suggest that bright light likely improved sleep quality and depression and mitigated worsening intensity of symptoms during the first three cycles of chemotherapy. However, features of bright light, e.g., treatment duration, frequency, and timing in relation to chemotherapy treatment require further investigation.
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影响因子：
1.9
作者：
Berger, Ann M;Parker, Kathy P;Hall, Martica
通讯作者：
Hall, Martica
DOI：
10.2114/jpa.21.87
发表时间：
2002-03-01
期刊：
Journal of Physiological Anthropology and Applied Human Science
影响因子：
--
作者：
Kuller, Rikard
通讯作者：
Kuller, Rikard
影响因子：
1.1
作者：
Manir, Kazi S.;Bhadra, Kallol;Sarkar, Shyamal K.
通讯作者：
Sarkar, Shyamal K.
影响因子：
5.7
作者：
Kanathur, Naveen;Harrington, John;Lee-Chiong, Teofilo, Jr.
通讯作者：
Lee-Chiong, Teofilo, Jr.
DOI：
10.1093/jnci/85.5.365
发表时间：
1993-03-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
AARONSON, NK;AHMEDZAI, S;TAKEDA, F
通讯作者：
TAKEDA, F