DISTRIBUTION AND TURNOVER OF CHOLESTEROL IN HUMANS
DISTRIBUTION AND TURNOVER OF CHOLESTEROL IN HUMANS
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DOI：
10.1172/jci106079
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发表时间：
1969-01-01
影响因子：
15.9
通讯作者：
GOODMAN, DS
中科院分区：
文献类型：
--
作者：
NESTEL, PJ;WHYTE, HM;GOODMAN, DS
本文对22名受试者的胆固醇代谢的某些参数与体重的关系进行了研究。胆固醇-4-14 C，与血浆脂蛋白复合，静脉注射，并从所得的比活性-时间曲线的胆固醇周转的指数进行了计算。这些是基于Goodman和Noble先前描述的双池模型，包括对两个池的大小、系统中胆固醇的产生速率、胆固醇从两个池中去除的速率常数以及池之间的转移的估计，和胆固醇代谢清除率之间的关系，采用单因素和多元回归分析来确定胆固醇的周转和分布，在更快速周转的A池中的胆固醇量（可能包括肝脏、血浆、红细胞和部分内脏如肠中的胆固醇）从14.9 g变化到32.7 g。合并液A的血浆外部分的平均值为17.9 g。通过某些假设，可以得出样本池B（样本池A以外组织中的可交换胆固醇）大小的可能下限和上限估计值，平均为35 g和60 g。胆固醇的日生成率（假定相当于总周转率）在0.73和1.68 g/day之间变化。胆固醇的生成率和池B的大小与总体显著相关，特别是与超重体重显著相关。当排除血浆含量时，合并液A中的胆固醇含量与体重无关。对于理想体重的个体，生产率为1.10 g/天，池B的大小在32和53 g之间。对于每千克超重，预期增量分别为0.0220 g/天和0.90 g。血浆胆固醇浓度与两个样本池中的胆固醇生成速率或量无关。然而，它与从合并液A中去除的分数和胆固醇的代谢清除率呈负相关，这表明排泄不足可能在高胆固醇血症的发生中具有重要意义。
The relationships between some parameters of cholesterol metabolism and body weight were studied in 22 subjects. Cholesterol-4-14C, complexed with plasma lipoprotein, was injected intravenously and from the resultant specific activity-time curves a number of indexes of cholesterol turnover were calculated. These were based on the two-pool model previously described by Goodman and Noble and included estimates of the sizes of the two pools, the production rate of cholesterol in the system, the rate constants for cholesterol removal from the two pools and transfer between the pools, and the metabolic clearance of cholesterol.Single and multiple regression analysis was used to define the relationships between the turnover and distribution of cholesterol and the total weight and fat content of the body.The amount of cholesterol in the more rapidly turning over pool A, which probably includes cholesterol in liver, plasma, erythrocytes, and part of the viscera such as intestine, varied from 14.9 to 32.7 g. The mean value for the extraplasma part of pool A was 17.9 g. Making certain assumptions it was possible to derive estimates of the probable lower and upper values for size of pool B (exchangeable cholesterol in tissues other than in pool A), which were, on average, 35 and 60 g. The daily production rate of cholesterol (assumed to be equivalent to total turnover rate) varied between 0.73 and 1.68 g/day.The production rate of cholesterol and the size of pool B were significantly related to total body, and particularly to excess body, weight. When the plasma content was excluded, the amount of cholesterol in pool A was not related to weight. For a body of ideal weight the production rate was 1.10 g/day and the size of pool B between 32 and 53 g. For each kilogram of excess weight the expected increments were 0.0220 g/day and 0.90 g, respectively.The plasma cholesterol concentration was not related to the production rate or to the amount of cholesterol in the two pools. It was, however, inversely related to the fractional rate of removal from pool A and to the metabolic clearance rate of cholesterol which suggests that inadequate excretion could be of importance in the development of hypercholesterolemia.