Physical activity in adulthood: genes and mortality.
Physical activity in adulthood: genes and mortality.
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DOI：
10.1038/srep18259
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发表时间：
2015-12-15
影响因子：
4.6
通讯作者：
Kujala UM
中科院分区：
文献类型：
--
作者：
Karvinen S;Waller K;Silvennoinen M;Koch LG;Britton SL;Kaprio J;Kainulainen H;Kujala UM
观察性研究报告说，休闲时间的身体活动与全因死亡率之间存在强烈的负相关关系。尽管基于人群的相关性提供了提示性证据，但科学家们在基线健康的个体中进行的对照干预研究中未能显示身体活动对死亡风险的有益影响。另一方面，众所周知，高心肺功能是降低死亡率的有力预测因素，甚至比体力活动水平本身更强大。在这里，在动物和/或人类双胞胎中，我们表明相同的遗传因素影响身体活动水平，心肺健康和死亡风险。先前对人类的观察性随访研究表明，通过体育活动水平增加健身可以延长寿命;然而，我们对实验室大鼠进行的对照干预研究与这些发现形成了鲜明对比。此外，我们没有发现任何证据的建议协会使用成对分析的同卵双胞胎对谁是不一致的，在他们的身体活动水平。基于我们的动物和人类研究结果，我们提出遗传多效性可能部分解释了经常观察到的高基线体力活动与后来人类死亡率降低之间的关联。
Observational studies report a strong inverse relationship between leisure-time physical activity and all-cause mortality. Despite suggestive evidence from population-based associations, scientists have not been able to show a beneficial effect of physical activity on the risk of death in controlled intervention studies among individuals who have been healthy at baseline. On the other hand, high cardiorespiratory fitness is known to be a strong predictor of reduced mortality, even more robust than physical activity level itself. Here, in both animals and/or human twins, we show that the same genetic factors influence physical activity levels, cardiorespiratory fitness, and risk of death. Previous observational follow-up studies in humans suggest that increasing fitness through physical activity levels could prolong life; however, our controlled interventional study with laboratory rats bred for low and high intrinsic fitness contrast with these findings. Also, we find no evidence for the suggested association using pairwise analysis among monozygotic twin pairs who are discordant in their physical activity levels. Based on both our animal and human findings, we propose that genetic pleiotropy might partly explain the frequently observed associations between high baseline physical activity and later reduced mortality in humans.