Longevity-associated mitochondrial DNA 5178 A/C polymorphism and blood pressure in the Japanese population
Longevity-associated mitochondrial DNA 5178 A/C polymorphism and blood pressure in the Japanese population
复制标题
DOI：
10.1038/sj.jhh.1001632
复制
发表时间：
2004
影响因子：
2.7
通讯作者：
A. Kokaze;M. Ishikawa;N. Matsunaga;M. Yoshida;Y. Sekine;K. Sekiguchi;M. Harada;M. Satoh;K. Teruya;N. Takeda;S. Fukazawa;Y. Uchida;Y. Takashima
中科院分区：
文献类型：
--
作者：
A. Kokaze;M. Ishikawa;N. Matsunaga;M. Yoshida;Y. Sekine;K. Sekiguchi;M. Harada;M. Satoh;K. Teruya;N. Takeda;S. Fukazawa;Y. Uchida;Y. Takashima
据报道，线粒体DNA5178腺嘌呤/胞嘧啶(mt5178 A/C)基因多态性，又称NADH脱氢酶亚单位2-237蛋氨酸/亮氨酸(ND2-237 Met/Leu)基因多态性，可能与日本人的长寿有关，mt5178A基因可能具有抗动脉粥样硬化作用。为了确定mt5178 A/C多态是否影响血压，我们对412名健康日本人进行了基因分型，并进行了一项横断面研究，调查了基因型与血压的关系。Mt5178A基因携带者的平均舒张压比mt5178C基因携带者高3.2毫米汞柱(P=0.040)。在男性中，mt5178 A/C基因型间的收缩压或舒张压差异无统计学意义。然而，mt5178 A/C基因型与习惯性饮酒对血压的影响显著相关。在调整了几个因素后，携带mt5178C的男性，日常饮酒者的收缩压和舒张压都显著高于偶尔饮酒者(分别为0.002和0.002)和不饮酒者(分别为0.001和0.001)，而在携带mt5178C的男性中，无论饮酒与否，血压都没有显著差异。这些结果提示mt5178 A/C(=ND2-237 Met/Leu)基因多态性可能既影响日本女性的舒张压，也影响日本男性饮酒后的升压效应。
It has been reported that the mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism, also called NADH dehydrogenase subunit 2-237 methionine/leucine (ND2-237 Met/Leu) polymorphism, may be associated with longevity in Japanese individuals, and that the mt5178A genotype may have an antiatherogenic influence. To determine whether mt5178 A/C polymorphism influences blood pressure, we genotyped 412 healthy Japanese individuals and performed a cross-sectional study investigating the relationship between genotype and blood pressure. In women with mt5178A, the mean diastolic blood pressure was higher than in those with mt5178C by 3.2 mmHg (P= 0.040). In men, no statistically significant difference in systolic or diastolic blood pressure was observed between mt5178 A/C genotypes. However, a significant correlation between mt5178 A/C genotypes and the effects of habitual drinking on blood pressure was found. After adjustment for several factors, in men carrying mt5178C, both systolic and diastolic blood pressure were significantly higher in daily drinkers than in occasional (P= 0.002 and 0.002, respectively) as well as nondrinkers (P< 0.001 and 0.001, respectively), whereas in men carrying mt5178A, no significant differences in blood pressure were detected, irrespective of alcohol consumption. These results suggest that mt5178 A/C (= ND2-237 Met/Leu) polymorphism may influence both diastolic blood pressure in Japanese women and the blood-pressure-increasing effect of drinking in Japanese men.