Functional MRI measurement of language lateralization in Wada-tested patients
Functional MRI measurement of language lateralization in Wada-tested patients
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DOI：
10.1093/brain/118.6.1411
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发表时间：
1995-12-01
期刊：
影响因子：
14.5
通讯作者：
Morrell, MJ
中科院分区：
文献类型：
--
作者：
Desmond, JE;Sum, JM;Morrell, MJ
本研究采用功能磁共振成像（fMRI）技术，对7例有颞叶癫痫病史的患者进行了语言侧化的非侵入性测量。4例患者为左半球优势，3例为右半球优势的语言。他们接受功能磁共振成像扫描，同时对视觉呈现的单词进行语义或感知判断。额下回（部三角和部眶）和邻近的眶皮质，对应于部分Brodmann区45，46和47的区域，表现出显着增加的激活语义相对于知觉判断。激活增加的偏侧化与Wada测试评估的7名患者中的每一名的半球语言优势一致。这些结果表明，除了提供一个工具，用于调查人类的认知过程，功能磁共振成像具有显着的临床潜力，作为一种非侵入性措施的语言侧化。
In this study the Else of functional MRI (fMRI) for measuring language lateralization non-invasively was examined The subjects were seven patients with histories of temporal lobe epilepsy who had undergone Wada testing for pre-surgical evaluation. Four patients were left-hemisphere-dominant and three were right-hemisphere-dominant for language. They received fMRI scans while they made semantic or perceptual judgments about visually presented words. Regions of the inferior frontal gyrus (pars triangularis and pars orbitalis) and neighbouring orbital cortex, corresponding to portions of Brodmann areas 45, 46 and 47, exhibited significant increases in activation during semantic relative to perceptual judgments. Lateralization of the increases in activation were consistent with the Wada test assessments of hemispheric language dominance in each of the seven patients. These results suggest that, in addition to providing a tool for investigating human cognitive processes, fMRI has significant clinical potential as a non-invasive measure of language lateralization.