A Pd-labile fluoroquinolone prodrug efficiently prevents biofilm formation on coated surfaces
A Pd-labile fluoroquinolone prodrug efficiently prevents biofilm formation on coated surfaces
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DOI：
10.1039/d4ob00014e
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发表时间：
2024-02-07
影响因子：
3.2
通讯作者：
Sieber，Stephan A.
中科院分区：
文献类型：
--
作者：
Braun，Josef;Ortega-Liebana，M. Carmen;Sieber，Stephan A.
植入物表面附着的细菌是抗生素治疗的主要挑战。我们介绍了水凝胶涂层表面负载量身定做的钯纳米片，催化释放抗生素从非活性前体药物。被掩盖的和抗生素无效的氟喹诺酮类似物在表面被有效地激活，并防止金黄色葡萄球菌生物被膜的形成。
Surface-adhered bacteria on implants represent a major challenge for antibiotic treatment. We introduce hydrogel-coated surfaces loaded with tailored Pd-nanosheets which catalyze the release of antibiotics from inactive prodrugs. Masked and antibiotically inactive fluoroquinolone analogs were efficiently activated at the surface and prevented the formation of Staphylococcus aureus biofilms.