Prostate specific antigen density of the transition zone for early detection of prostate cancer
Prostate specific antigen density of the transition zone for early detection of prostate cancer
复制标题
DOI：
10.1016/s0022-5347(01)62911-2
复制
发表时间：
1998-08-01
影响因子：
6.6
通讯作者：
Marberger, M
中科院分区：
文献类型：
--
作者：
Djavan, B;Zlotta, AR;Marberger, M
目的：我们比较了几个前列腺特异性抗原（PSA）参数的能力，包括整个前列腺和移行区的PSA密度，游离PSA百分比和PSA速度，以提高前列腺癌检测的特异性，并减少血清PSA水平为4至10.0 ng的男性不必要的活检。ml.材料和方法：这项前瞻性研究包括559名连续的男性，他们被转诊进行早期前列腺检测或下尿路症状，血清PSA为4.0至10.0 ng。ml.所有男性均接受前列腺超声检查和六分仪活检，并额外进行2次移行区活检。对直肠指诊异常的患者进行特殊活检。在所有情况下，如果第一次活检为阴性，则在6周内进行另一组活检。用单因素和多因素分析以及受试者工作特征（ROC）曲线评价了PSA密度、PSA移行区、PSA速度和游离PSA百分比提高PSA检测前列腺癌能力的能力。平均血清PSA、PSA流速、PSA密度和PSA移行带均高于对照组（p
Purpose: We compare the ability of several prostate specific antigen (PSA) parameters, including PSA density of the whole prostate and of the transition zone, percent free PSA and PSA velocity, to enhance the specificity for prostate cancer detection and to reduce unnecessary biopsies in men with serum PSA levels of 4 to 10.0 ng./ml.Materials and Methods: This prospective study included 559 consecutive men referred for early prostate detection or lower urinary tract symptoms who had a serum PSA of 4.0 to 10.0 ng./ml. All men underwent prostatic ultrasonography and sextant biopsy with 2 additional transition zone biopsies. Specific biopsies of abnormal findings on digital rectal examination were also performed. In all cases if first biopsies were negative an additional set of biopsies was performed within 6 weeks. The ability of PSA density, PSA transition zone, PSA velocity and percent free PSA to improve the power of PSA in the detection of prostate cancer was evaluated with univariate and multivariate analyses as well as receiver operating characteristics (ROC) curves.Results: Of 559 patients 342 had histologically confirmed benign prostatic hyperplasia and 217 had prostate cancer. Mean serum PSA, PSA velocity, PSA density and PSA transition zone were statistically higher (p