CONCENTRATION OF TETRACYCLINE IN HUMAN GINGIVAL FLUID AFTER SINGLE DOSES
CONCENTRATION OF TETRACYCLINE IN HUMAN GINGIVAL FLUID AFTER SINGLE DOSES
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DOI：
10.1111/j.1600-051x.1981.tb02351.x
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发表时间：
1981-01-01
影响因子：
6.7
通讯作者：
SOCRANSKY, SS
中科院分区：
文献类型：
--
作者：
GORDON, JM;WALKER, CB;SOCRANSKY, SS
在单次口服250或500 mg四环素后，测量牙龈液中四环素的浓度。6名志愿者接受250 mg或500 mg四环素单次给药，在前2 h内每隔15 min采集一次牙龈液，在随后2 h内每隔30 min采集一次牙龈液，并在第5、6和7 h采集一次牙龈液。4名志愿者接受250 mg或500 mg单次给药，每小时采样一次，持续24 h。使用龈沟内技术从4个牙龈部位采集牙龈液，并通过手指穿刺获得血液。牙龈液中四环素的浓度在3.5-7小时达到峰值，达到通常在5-12 μ g/ml范围内的平均水平。血液水平在3-4小时达到峰值，并达到1.0-2.6 μ g/ml之间的值。四环素在单次给药后至少19 h可在牙龈液中检测到，但很少在24 h时检测到。单次给药后，牙龈液中的四环素通常是血液水平的2-10倍。
The concentration of tetracycline in gingival fluid was measured following the oral administration of single doses of 250 or 500 mg. Six volunteers received a single dose of 250 mg or 500 mg of tetracycline and gingival fluid was sampled at 15 min intervals during the first 2 h, 30 min intervals for the following 2 h and at hours 5, 6 and 7. Four volunteers were given a single dose of 250 mg or 500 mg and were sampled every hour for 24 h. Gingival fluid was sampled using an intracrevicular technique from 4 gingival sites and blood was obtained by finger puncture. The concentration of tetracycline in gingival fluid peaked at 3.5-7 h achieving average levels typically in the range of 5-12 .mu.g/ml. Blood levels peaked at 3-4 h and reached values between 1.0-2.6 .mu.g/ml. Tetracycline was detectable in gingival fluid at least 19 h after a single dose but rarely was detectable at 24 h. Tetracycline in the gingival fluid was typically 2-10 times blood levels after a single dose.