Inhibition of gene expression by peptide nucleic acids in cultured cells
Inhibition of gene expression by peptide nucleic acids in cultured cells
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DOI：
10.1081/ncn-120023081
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发表时间：
2003-01-01
影响因子：
1.3
通讯作者：
Xodo, LE
中科院分区：
文献类型：
--
作者：
Cogoi, S;Rapozzi, V;Xodo, LE
我们已经在培养的细胞中测试了反义和反基因PNA以序列特异性方式抑制白血病和胰腺癌细胞中癌基因表达的能力。观察到的结果似乎很有希望，并表明PNA可能在未来发挥重要作用，靶向疾病相关基因。
We have tested in cultured cells the capacity of antisense and antigene PNAs to inhibit, in a sequence specific manner, the expression of oncogenes in leukaemia and pancreatic carcinoma cells. The results observed appeared promising and suggest that PNA may play in the future an important role in targeting disease-related genes.