Chromatin and oxygen sensing in the context of JmjC histone demethylases.
Chromatin and oxygen sensing in the context of JmjC histone demethylases.
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DOI：
10.1042/bj20140754
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发表时间：
2014-09-15
期刊：
影响因子：
--
通讯作者：
Rocha S
中科院分区：
文献类型：
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作者：
Shmakova A;Batie M;Druker J;Rocha S
对氧气供应的变化做出适当的反应对于多细胞生物的生存至关重要。从分子上讲，细胞已经进化出复杂的基因表达程序来处理这种压力条件。尽管人们认识到基因表达是通过缺氧中转录和翻译的变化来协调的，但对染色质变化如何允许转录发生知之甚少。协调染色质结构和缺氧诱导的转录程序之间的缺失环节可能是一类称为JmjC（Jumonji C）酶的双加氧酶的形式，其中大多数是组蛋白脱甲基酶。在本综述中，我们将重点介绍JmjC组蛋白去甲基化酶的功能，以及它们如何在缺氧条件下作为染色质的氧传感器。本文还将对JmjC组蛋白去甲基化酶在生物体发育和人类疾病中的作用进行综述。
Responding appropriately to changes in oxygen availability is essential for multicellular organism survival. Molecularly, cells have evolved intricate gene expression programmes to handle this stressful condition. Although it is appreciated that gene expression is co-ordinated by changes in transcription and translation in hypoxia, much less is known about how chromatin changes allow for transcription to take place. The missing link between co-ordinating chromatin structure and the hypoxia-induced transcriptional programme could be in the form of a class of dioxygenases called JmjC (Jumonji C) enzymes, the majority of which are histone demethylases. In the present review, we will focus on the function of JmjC histone demethylases, and how these could act as oxygen sensors for chromatin in hypoxia. The current knowledge concerning the role of JmjC histone demethylases in the process of organism development and human disease will also be reviewed.