Sex-specific components of frailty in C57BL/6 mice
Sex-specific components of frailty in C57BL/6 mice
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DOI：
10.18632/aging.102114
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发表时间：
2019-07-31
期刊：
影响因子：
5.2
通讯作者：
Thompson, LaDora, V
中科院分区：
文献类型：
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作者：
Baumann, Cory W.;Kwak, Dongmin;Thompson, LaDora, V
许多与年龄相关的生化、生理和行为变化都是性别特有的。然而，性别如何影响脆弱啮齿动物的脆弱状态和死亡风险尚未确定。因此，这项研究的目的是描述虚弱小鼠在整个生命周期中的性别差异。对17个月大的雄性(n=29)和雌性(n=27)小鼠进行了根据性别调整的脆弱表型评估，包括体重、步行速度、力量、耐力和体力活动。无论性别，虚弱的小鼠与年龄匹配的非虚弱的小鼠相比，表现出功能障碍，而非虚弱的雌性通常拥有更高的体脂百分比，并且比非虚弱的雄性更活跃(p=0.12)。最后，这些数据表明，衰老的C57BL/6小鼠存在性别差异，如果根据性别调整脆弱标准，虚弱的患病率随着年龄的增长而增加，虚弱的小鼠在生命早期死亡，无论性别。
Many age-related biochemical, physiological and behavioral changes are known to be sex-specific. However, how sex influences frailty status and mortality risk in frail rodents has yet to be established. The purpose of this study was therefore to characterize sex differences in frail mice across the lifespan. Male (n=29) and female (n=27) mice starting at 17 months of age were assessed using a frailty phenotype adjusted according to sex, which included body weight, walking speed, strength, endurance and physical activity. Regardless of sex, frail mice were phenotypically dysfunctional compared to age-matched non-frail mice, while non-frail females generally possessed a higher body fat percentage and were more physically active than non-frail males (p = 0.12). In closing, these data indicate that sexual differences exist in aging C57BL/6 mice and if the frailty criteria are adjusted according to sex, the prevalence of frailty increases across age with frail mice dying early in life, regardless of sex.