Mortality in chemical workers potentially exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) 1945-94: an update
Mortality in chemical workers potentially exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) 1945-94: an update
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DOI：
10.1136/oem.58.1.24
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发表时间：
2001-01-01
影响因子：
4.9
通讯作者：
Cartmill, JB
中科院分区：
文献类型：
--
作者：
Burns, CJ;Beard, KK;Cartmill, JB
更新并添加到先前确定的可能接触除草剂2，4-二氯苯氧乙酸（2，4-D）的员工队列中。2，4-D和非霍奇金淋巴瘤之间的假定关联已经争论了十多年。方法队列成员是陶氏化学公司的男性雇员，他们在1945年至1994年底的任何时间制造或配制2，4-D。他们的死亡率的经验进行了比较，与国家的比率，并与超过40 000名其他公司员工谁在同一location.Results-330死亡观察1517人相比，365预期（标准化死亡率（SMR）= 0.90，95%置信区间（95%CI）0.81至1.01）。分析的任何死亡原因的SMR均未显著增加。与美国发生率相比，非霍奇金淋巴瘤（NHL）的SMR为1.00（95% CI 0.21 - 2.92）。与陶氏化学其他员工的内部比较显示，相对风险为2.63，（95% CI 0.85至8.33）。三名队列成员的死亡归因于肌萎缩侧索硬化症（ALS）。与公司其他员工相比，相对危险度为3.45（95%CI 1.10~11.11）。这些病例在不同时期（1947 - 9，1950 - 1和1968 - 86）用于生产或配制2，4-D，并持续不同的时间（1.3，1.8和12.5年）。结论：没有证据表明暴露于2，4-D与所有原因和总恶性肿瘤引起的死亡率之间存在因果关系。没有发现NHL的显著风险，尽管不是最初的假设，但注意到ALS的相对风险增加。这一发现没有得到其他动物和人类研究的支持。
Objective-To update and add to a previously identified cohort of employees potentially exposed to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D). The putative association between 2,4-D and non-Hodgkin's lymphoma has been debated for more than a decade.Methods-Cohort members were male employees of The Dow Chemical Company who manufactured or formulated 2,4-D any time from 1945 to the end of 1994. Their mortality experience was compared with national rates and with more than 40 000 other company employees who worked at the same location.Results-330 Deaths were observed among 1517 people compared with 365 expected (standardised mortality ratio (SMR)=0.90, 95% confidence interval (95% CI) 0.81 to 1.01). There were no significantly increased SMRs for any of the causes of death analyzed. When compared with the United States rates, the SMR for non-Hodgkin's lymphoma (NHL) was 1.00 (95% CI 0.21 to 2.92). The internal comparison with other Dow employees showed a non-significant relative risk of 2.63, (95% CI 0.85 to 8.33). Death was attributed to amyotrophic lateral sclerosis (ALS) for three cohort members. Compared with the other company employees, the relative risk was 3.45 (95% CI 1.10 to 11.11). The cases were employed in the manufacture or formulation of 2,4-D at different periods (1947-9, 1950-1, and 1968-86), and for varying durations of time (1.3, 1.8, and 12.5 years).Conclusion-There was no evidence of a causal association between exposure to 2,4-D and mortality due to all causes and total malignant neoplasms. No significant risk due to NHL was found. Although not an initial hypothesis, an increased relative risk of ALS was noted. This finding is unsupported by other animal and human studies.