Predictors of hair cortisol concentrations in older adults
Predictors of hair cortisol concentrations in older adults
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DOI：
10.1016/j.psyneuen.2013.10.007
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发表时间：
2014-01-01
影响因子：
3.7
通讯作者：
Stalder, Tobias
中科院分区：
文献类型：
--
作者：
Feller, Silke;Vigl, Matthaeus;Stalder, Tobias
年龄较大的人患压力相关疾病的风险增加，这与长期升高的皮质醇分泌有关。然而，导致这一年龄组内分泌改变的主要因素在很大程度上仍是未知的。这项横断面研究对来自波茨坦欧洲癌症与营养前瞻性调查（EPIC）研究的德国队列的654名中老年参与者（平均年龄：65.8岁；范围：47-82岁）的头发进行了长期综合皮质醇分泌模式的评估。毛发皮质醇浓度（HCC）从第一个头皮近3cm的毛发段开始测定，并评估了一些社会人口统计学、生活方式、人体测量学、疾病相关和心理参数。在简单的线性回归中，发现HCC随着参与者的年龄而增加，并且男性高于女性。HCC还与腰臀比、腰围、吸烟、流行的2型糖尿病、心理健康、白天睡眠、失业或退休呈正相关，与舒张压呈负相关。在完全相互调整后，只有年龄和吸烟仍然是HCC的独立预测因子。流行的2型糖尿病和HCC之间的相关性减弱，但在女性中仍然独立存在。同样，在女性中发现HCC与饮酒呈正相关。目前的结果证实了先前的证据，即HCC与年龄、性别、饮酒和2型糖尿病呈正相关，并增加了吸烟等因素可能导致老年人皮质醇水平升高的新知识。(C) 2013 Elsevier Ltd.版权所有。
People at older ages are at increased risk for developing stress-related diseases associated with chronically elevated cortisol secretion. However, the main factors contributing to such endocrine alterations in this age group are still largely unknown. This cross-sectional study examined patterns of long-term integrated cortisol secretion, as assessed in hair, in a sample of 654 participants in middle and old adulthood (mean age: 65.8 years; range: 47-82 years) from the German cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC) study in Potsdam. Hair cortisol concentrations (HCC) were determined from the first scalp-near 3 cm hair segment and several sociodemographic, lifestyle, anthropometric, disease-related, and psychological parameters were assessed. In simple linear regressions, HCC were found to increase with participants' age and to be higher in men compared to women. HCC also showed positive associations with waist-to-hip ratio, waist circumference, smoking, prevalent type 2 diabetes mellitus, mental health, daytime sleeping, and being unemployed or retired as well as a negative association with diastolic blood pressure. After full mutual adjustment, only age and smoking remained independent predictors of HCC. The association between prevalent type 2 diabetes mellitus and HCC was attenuated but still persisted independently in women. Similar, a positive relationship between HCC and alcohol consumption was found in women. The current results confirm previous evidence of positive associations of HCC with age, sex, alcohol consumption, and type 2 diabetes mellitus and add new knowledge on factors such as smoking that may contribute to elevated cortisol levels in people at older ages. (C) 2013 Elsevier Ltd. All rights reserved.