Bioactive oligosaccharide natural products.
Bioactive oligosaccharide natural products.
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生物活性寡糖天然产品。
DOI：
10.1039/c3np70128j
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发表时间：
2014-08
影响因子：
11.9
通讯作者：
Bachmann BO
中科院分区：
文献类型：
--
作者：
McCranie EK;Bachmann BO
寡糖天然产物靶向广泛的生物过程，包括破坏细胞壁生物合成、干扰细菌翻译和抑制人α-淀粉酶。相应地，低聚糖具有作为细菌感染和II型糖尿病等多种疾病的治疗的开发潜力。尽管其有效的和选择性的活动和潜在的临床相关性，分离的生物活性次级代谢寡糖是不太普遍的比其他类别的天然产物，其生物合成已收到相对较少的关注。本文综述了四类具有生物活性的寡糖的独特作用和生物合成方式：正糖霉素、默诺霉素、糖霉素和阿卡维他汀。
Oligosaccharide natural products target a wide spectrum of biological processes including disruption of cell wall biosynthesis, interference of bacterial translation, and inhibition of human α-amylase. Correspondingly, oligosaccharides possess potential for development as treatments of such diverse diseases as bacterial infections and type II diabetes. Despite their potent and selective activities and potential clinical relevance, isolated bioactive secondary metabolic oligosaccharides are less prevalent than other classes of natural products and their biosynthesis has received comparatively less attention. This review highlights the unique modes of action and biosynthesis of four classes of bioactive oligosaccharides: the orthosomycins, moenomycins, saccharomicins, and acarviostatins.