STUDIES OF 2 KINDS OF VIRUS PARTICLES WHICH COMPRISE INFLUENZA-A2 VIRUS STRAINS .3. MORPHOLOGICAL CHARACTERISTICS - INDEPENDENCE OF MORPHOLOGICAL AND FUNCTIONAL TRAITS
STUDIES OF 2 KINDS OF VIRUS PARTICLES WHICH COMPRISE INFLUENZA-A2 VIRUS STRAINS .3. MORPHOLOGICAL CHARACTERISTICS - INDEPENDENCE OF MORPHOLOGICAL AND FUNCTIONAL TRAITS
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DOI：
10.1084/jem.112.5.945
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发表时间：
1960-01-01
影响因子：
15.3
通讯作者：
TAMM, I
中科院分区：
文献类型：
--
作者：
CHOPPIN, PW;MURPHY, JS;TAMM, I
将7株A2型流感病毒在鸡胚中连续传代，并在电子显微镜下观察传代的形态特征。随着连续传代，早期传代中显着的丝状外观转变为后期传代中几乎完全球形的外观。转化为球形形态所需的传代次数因菌株不同而异。发现丝球变异与区分“+”和“-”甲型2型流感病毒颗粒的特性无关，并且获得了“+”和“-”病毒颗粒的高度丝状和球形群体。讨论了这些独立标记对对于遗传研究的有用性。
Seven strains of influenza A2 virus were serially passed in the chick embryo, and morphological characteristics of the passages were examined in the electron microscope. With serial passage there was a change from a prominently filamentous appearance in early passages to an almost entirely spherical appearance in later passages. The number of passages required for the conversion to spherical morphology varied with different strains. The filament-sphere variation was found to be independent of the properties which differentiate "+" and "-" influenza A2 virus particles, and both highly filamentous and spherical populations of "+" and of "-" virus particles were obtained. The usefulness of these pairs of independent markers for genetic studies is discussed.