Effect of surfactant on the characteristics of biodegradable microcapsules.
Effect of surfactant on the characteristics of biodegradable microcapsules.
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表面活性剂对生物可降解微胶囊特性的影响
DOI：
10.1163/1568562053783696
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Mandal,TarunK
中科院分区：
文献类型：
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作者：
Graves,RichardA;Moiseyev,Raisa;Freeman,Thomas;Mandal,TarunK
本项目的目的是评价几种亲脂性表面活性剂对PLGA微囊性质的影响。以牛血清白蛋白为模型多肽。使用了7种不同的亲脂性表面活性剂，每种表面活性剂分别以0.1、0.5和1%(w/w)的三种不同浓度使用。采用复乳-溶剂挥发法制备微胶囊。微胶囊均为球形，表面光滑。微囊的中位数尺寸在4~49μm之间，zeta电位在−26~−43 mV之间。包封率在8%~45%之间变化。包埋效率似乎取决于表面活性剂的类型和浓度。35天内BSA的累积释放百分比从18%到78%不等。总而言之，微胶囊的物理特性似乎不会受到表面活性剂类型的很大影响。所有样品的颗粒大小似乎都表现出多分散性。颗粒电荷取决于表面活性剂的类型和浓度。这些微胶囊的整体溶出非常缓慢。
The objective of this project was to evaluate the effect of several lipophilic surfactants on the characteristics of PLGA microcapsules. BSA was used as a model peptide. Seven different lipophilic surfactants were used and each of the surfactants was used at three different concentrations, 0.1, 0.5 and 1% (w/w), respectively. The microcapsules were prepared using the double emulsion solvent evaporation technique. The microcapsules were all spherical in shape with a smooth surface. The median size of the microcapsules varied between 4 and 49μm. The zeta potential of the microcapsules varied between −26 and −43 mV. The efficiency of encapsulation varied between 8 and 45%. Efficiency of encapsulation appears to be dependant on both the type and concentration of the surfactant. Cumulative percent of BSA released up to 35 days varied from 18 to 78%. In conclusion, the physical characteristics of the microcapsules do not appear to be greatly affected by the type of surfactant. All of the samples appear to show polydispersity in their particle sizes. Particle charge depended on both the type and concentration of the surfactant. The overall dissolution of these microcapsules was very slow.