In vivo detection of myelin proteins in cervical lymph nodes of MS patients using ultrasound-guided fine-needle aspiration cytology
In vivo detection of myelin proteins in cervical lymph nodes of MS patients using ultrasound-guided fine-needle aspiration cytology
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DOI：
10.1016/j.jneuroim.2004.12.018
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发表时间：
2005-04-01
影响因子：
3.3
通讯作者：
Castelijns, JA
中科院分区：
文献类型：
--
作者：
Fabriek, BO;Zwernmer, JNP;Castelijns, JA
颈部淋巴结（CLN）已被描述为大脑的第一个淋巴样引流部位。在本研究中，我们使用超声引导细针穿刺细胞学（USgFNAC）从多发性硬化症（MS）患者和HC患者的未增大的CLN中获取细胞，并研究是否可以检测到髓磷脂蛋白。巨噬细胞含有髓鞘碱性蛋白（MBP）和蛋白脂质蛋白（PLP）在所有MS患者的CLN中都被发现，而这些只在少数HC患者中被检测到。这种新颖的方法允许研究大脑的第一个引流部位，用于ms的体内免疫调节分析(C) 2005 Elsevier B.V.。
Cervical lymph nodes (CLN) have been described to be the first lymphoid draining site of the brain. In this study we used ultrasound guided fine needle aspiration cytology (USgFNAC) to obtain cells, in vivo, from non-enlarged CLN of multiple sclerosis (MS) patients and HCs (HC), and investigated whether myelin proteins could be detected.Macrophages containing myelin basic protein (MBP) and proteolipid protein (PLP) were found in CLN of all MS patients, whereas these could only be detected in a minority of HC. This novel approach allows investigation of the first draining site of the brain for in vivo analysis of the immune regulation of MS. (C) 2005 Elsevier B.V. All rights reserved.