Genetic and molecular characterization of a novel reassortant H2N8 subtype avian influenza virus isolated from a domestic duck in Zhejiang Province in China
Genetic and molecular characterization of a novel reassortant H2N8 subtype avian influenza virus isolated from a domestic duck in Zhejiang Province in China
复制标题
从中国浙江省家鸭中分离出的新型重配 H2N8 亚型禽流感病毒的遗传和分子特征
DOI：
10.1007/s11262-016-1368-0
复制
发表时间：
2016-12-01
期刊：
影响因子：
1.6
通讯作者：
Wu, Nanping
中科院分区：
文献类型：
--
作者：
Wu, Haibo;Peng, Xiuming;Wu, Nanping
H2亚型流感病毒在家畜中的循环增加了人类接触这些病毒的风险。2013年在浙江省活禽市场进行禽流感病毒监测时，从一只家鸭中分离出H2N8禽流感病毒（AIV）。系统发育树表明，该毒株是一种新的重组病毒，源自东亚水禽和家禽的多种AIV亚型。虽然这种重组菌株在小鼠中表现出低致病性，但它能够在没有事先适应的情况下在小鼠的肺部复制。需要对lpm中的家鸭进行持续监测，以便及早发现家禽和人类中的AIV暴发。
The circulation of the H2 subtype influenza viruses in domestic animals increases the risk of human exposure to these viruses. An H2N8 avian influenza virus (AIV) was isolated from a domestic duck during AIV surveillance of poultry in live poultry markets (LPMs) in Zhejiang Province, Eastern China, in 2013. The phylogenetic trees suggested that this strain is a novel reassortant virus derived from multiple AIV subtypes from aquatic birds and poultry in Eastern Asia. Although this reassortant strain exhibited low pathogenicity in mice, it was able to replicate in the lungs of the mice without prior adaptation. Continued surveillance of domestic ducks in LPMs is required for early detection of AIV outbreaks in poultry and humans.