IMMUNE-RESPONSE IN MICE THAT LACK THE INTERFERON-GAMMA RECEPTOR
IMMUNE-RESPONSE IN MICE THAT LACK THE INTERFERON-GAMMA RECEPTOR
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DOI：
10.1126/science.8456301
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发表时间：
1993-03-19
期刊：
影响因子：
56.9
通讯作者：
AGUET, M
中科院分区：
文献类型：
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作者：
HUANG, S;HENDRIKS, W;AGUET, M
干扰素-γ（IFN-γ）发挥多效性作用，包括抗病毒活性、刺激巨噬细胞和自然杀伤细胞以及增加主要组织相容性复合体抗原的表达。没有IFN-γ受体的小鼠没有明显的异常，它们的免疫系统似乎发育正常。然而，突变小鼠有一个缺陷的天然抵抗力，他们增加了感染单核细胞增生李斯特菌和牛痘病毒的易感性，尽管正常的细胞毒性和T辅助细胞反应。免疫球蛋白同种型分析表明，IFN-γ是正常抗原特异性免疫球蛋白G2 a反应所必需的。这些突变小鼠提供了通过转基因细胞或组织特异性重建功能性受体进一步阐明IFN-γ介导的功能的可能性。
Interferon-gamma (IFN-gamma) exerts pleiotropic effects, including antiviral activity, stimulation of macrophages and natural killer cells, and increased expression of major histocompatibility complex antigens. Mice without the IFN-gamma receptor had no overt anomalies, and their immune system appeared to develop normally. However, mutant mice had a defective natural resistance; they had increased susceptibility to infection by Listeria monocytogenes and vaccinia virus despite normal cytotoxic and T helper cell responses. Immunoglobulin isotype analysis revealed that IFN-gamma is necessary for a normal antigen-specific immunoglobulin G2a response. These mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.