CONGENITAL HEART-DISEASE IN INFANTS WITH DOWNS-SYNDROME
CONGENITAL HEART-DISEASE IN INFANTS WITH DOWNS-SYNDROME
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DOI：
10.1097/00007611-199407000-00010
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发表时间：
1994-07-01
影响因子：
1.1
通讯作者：
FINLEY, WH
中科院分区：
文献类型：
--
作者：
WELLS, GL;BARKER, SE;FINLEY, WH
本文回顾了118例唐氏综合征新生儿的医疗记录，以记录超声心动图显示的先天性心脏病（CHD）类型。102名接受超声心动图检查的婴儿中，49名（48%）有心脏缺陷；其中47人有21三体，2人有不平衡的易位核型。在53名（52%）没有心脏缺陷的患者中，除了1名具有镶嵌核型和1名具有易位核型外，其余均为三体。最常见的心脏畸形是房室管，其次是室间隔缺损、房间隔缺损、动脉导管未闭和法洛四联症。超声心动图对这些婴儿的好处是早期发现冠心病，积极的管理以防止未来的并发症，如果婴儿没有冠心病，可以让父母放心。
Medical records of 118 newborn infants with Down's syndrome were reviewed to document the types of congenital heart disease (CHD) in those having echocardiography. Of 102 infants having echocardiography, 49 (48%) had heart defects; 47 of these had trisomy 21 and 2 had unbalanced translocation karyotypes. Of the 53 (52%) who did not have heart defects, all had trisomy except 1 with a mosaic karyotype and 1 with a translocation karyotype. The most common heart malformation was an atrioventricular canal, followed in frequency by ventricular septal defect, atrial septal defect, patent ductus arteriosus, and tetralogy of Fallot. Benefits of echocardiography in such infants are early detection of CHD, with aggressive management to prevent future complications, and reassurance to parents if the infant does not have CHD.