Changes in the Pleural Cavity by Pleurodesis Using Talc or OK-432: An Experimental Study
Changes in the Pleural Cavity by Pleurodesis Using Talc or OK-432: An Experimental Study
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DOI：
10.1007/s00595-010-4275-3
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发表时间：
2011-01-01
期刊：
影响因子：
2.5
通讯作者：
Shirouzu, Kazuo
中科院分区：
文献类型：
--
作者：
Muta, Fumihiko;Takamori, Shinzo;Shirouzu, Kazuo
目的.目的观察滑石粉或OK-432诱导胸膜固定术后胸膜腔的变化。将总共30只大鼠分为三组：生理盐水组（对照组，n = 10）、给予400 mg/kg滑石粉的组（滑石粉组，n = 10）和给予0.3 KE/kg OK-432的组（OK-432组，n = 10）。胸腔给药后第30天进行胸膜腔检查和评分。滑石粉组和OK-432组的肉眼或显微镜胸膜固定术评分均显著高于对照组（P < 0.05）。经显微镜评价，滑石粉组的胸膜固定术评分显著高于OK-432组（P < 0.01）。胸膜厚度大部分位于脏层胸膜，壁层胸膜非常薄。滑石粉组的脏层胸膜厚度显著高于OK-432组（P < 0.005）。病理学上，滑石粉组胸膜增厚由纤维组织组成，胸膜间皮损伤，在间皮下纤维组织和肺泡内可见滑石粉颗粒。滑石粉胸膜固定术比OK-432诱导的胸膜固定术诱导的胸膜腔变化更显著。
Purpose. To define the changes in the pleural cavity after pleurodesis induced by talc or OK-432.Methods. A total of 30 rats were divided into three groups: a normal saline group (control group, n = 10), a group administered 400 mg/kg talc (talc group, n = 10), and a group administered 0.3 KE/kg OK-432 (OK-432 group, n = 10). Pleural cavities were examined and scored on the 30th day after the intrapleural administration of each agent.Results.. Both the talc group and OK-432 group showed significantly higher macroscopic or microscopic pleurodesis scores than the control group (P < 0.05). Upon microscopic evaluation, the pleurodesis scores in the talc group were significantly higher than those in the OK-432 group (P < 0.01.). The majority of the pleural thickness was found on the visceral pleura, and the parietal pleura was very thin. The thickness of the visceral pleura in the talc group was significantly higher than that in the OK-432 group (P < 0.005). Pathologically, the pleural thickening in the talc group consisted of fibrous tissue with injury of the pleural mesothelium, and talc particles were seen in the submesothelial fibrotic tissue and inside the alveoli.Conclusions. Talc pleurodesis induces more marked changes in the pleural cavity than OK-432-induced pleurodesis.