CHIP, CCUS, and Other Acronyms: Definition, Implications, and Impact on Practice.
CHIP, CCUS, and Other Acronyms: Definition, Implications, and Impact on Practice.
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CHIP、CCUS 和其他缩写词：定义、含义和对实践的影响。
DOI：
10.1200/edbk_239083
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Ebert, Benjamin L
中科院分区：
文献类型：
--
作者：
DeZern, Amy E;Malcovati, Luca;Ebert, Benjamin L
原因不明的血细胞减少症对患者和临床医生来说都是一个临床挑战。这些细胞减少与骨髓增生异常综合征（MDS）等髓系肿瘤之间的关系目前是一个活跃的研究领域。基于已知与MDS相关的基因的体细胞突变的发现，我们对克隆造血的理解有了显著的发展。这导致了新的术语来描述MDS的前体状态，如克隆性造血不确定电位（CHIP）和克隆性细胞减少不确定意义（CCUS）。这些情况可能允许早期诊断，修改MDS的监测，并指导额外的治疗。本文综述了受影响患者在该领域的最新进展。
Unexplained blood cytopenias can be a clinical challenge for patients and clinicians alike. The relationship between these cytopenias and myeloid neoplasms like myelodysplastic syndromes (MDS) is currently an area of active research. There have been marked developments in our understanding of clonal hematopoiesis based on findings of somatic mutations in genes known to be associated with MDS. This has led to newer terms to describe precursor states to MDS, such as clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined significance (CCUS). These conditions may allow earlier diagnosis, modify surveillance for MDS, and guide additional therapies. This review summarizes recent updates in the field for affected patients.